CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020600
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ER membrane protein complex subunit 2 
Protein Synonyms/Alias
 Tetratricopeptide repeat protein 35; TPR repeat protein 35 
Gene Name
 Emc2 
Gene Synonyms/Alias
 Kiaa0103; Ttc35 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
18TWEEMRDKMRKWREEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 REPEAT 87 120 TPR 1.
 REPEAT 155 188 TPR 2.
 REPEAT 192 225 TPR 3.
 MOD_RES 255 255 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 297 AA 
Protein Sequence
MAKVTERYDV TWEEMRDKMR KWREENSRNS EQIMEVGEEL INDYASKLGD DIWIIYEQVM 60
IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM ERYDDAIQLY DRILQEDPTN 120
TAARKRKIAI RKAQGKTVEA IRELNEYLEQ FVGDQEAWHE LAELYINEHD YAKAAFCLEE 180
LMMTNPHNHL YCQQYAEVKY TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA 240
SNPKASAKMK KDNIKYASWA ANQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS 297 
Gene Ontology
 GO:0072546; C:ER membrane protein complex; ISS:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF07719; TPR_2 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS