UniProt Accession

 GLK_ECOLI; P0A6V8; P46880; P78276 

Genbank Protein ID

 U22490; U00096; AP009048 

Genbank Nucleotide ID

 AAA64506.1; AAC75447.1; BAA16258.1 

Protein Name

 Glucokinase 

Protein Synonyms/Alias

 Glucose kinase 

Gene Name

 glk 

Gene Synonyms/Alias

 b2388; JW2385 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
3	*****MTKYALVGDV	acetylation	[1]
53	RVYLEEHKVEVKDGC	acetylation	[2]
128	GAEPVEGKPIAVYGA	acetylation	[2]
149	AHLVHVDKRWVSLPG	acetylation	[2]
214	NRLPENLKPKDITER	acetylation	[1, 2]
216	LPENLKPKDITERAL	acetylation	[1, 2]
273	PRFLEFFKASGFRAA	acetylation	[2]
288	FEDKGRFKEYVHDIP	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. 

Sequence Annotation

 NP_BIND 8 13 ATP (Potential).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 321 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004340; F:glucokinase activity; IDA:EcoCyc.
 GO:0016052; P:carbohydrate catabolic process; IGI:EcoCyc.
 GO:0006096; P:glycolysis; IEA:HAMAP. 

Interpro

 IPR003836; Glucokinase. 

Pfam

 PF02685; Glucokinase 

SMART

  

PROSITE

  

PRINTS