CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012095
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc transporter ZIP6 
Protein Synonyms/Alias
 Estrogen-regulated protein LIV-1; Solute carrier family 39 member 6; Zrt- and Irt-like protein 6; ZIP-6 
Gene Name
 SLC39A6 
Gene Synonyms/Alias
 LIV1; ZIP6 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
77LSVEGFRKLLQNIGIubiquitination[1, 2, 3]
86LQNIGIDKIKRIHIHubiquitination[2]
88NIGIDKIKRIHIHHDubiquitination[2]
229TPPSVTSKSRVSRLAubiquitination[2]
249ESVSEPRKGFMYSRNubiquitination[2]
311LIHTSEKKAEIPPKTubiquitination[2]
456DKKKKNQKKPENDDDubiquitination[1]
457KKKKNQKKPENDDDVubiquitination[1]
467NDDDVEIKKQLSKYEubiquitination[1]
468DDDVEIKKQLSKYESubiquitination[1]
472EIKKQLSKYESQLSTubiquitination[1]
483QLSTNEEKVDTDDRTubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May act as a zinc-influx transporter. 
Sequence Annotation
 CARBOHYD 67 67 N-linked (GlcNAc...).
 CARBOHYD 68 68 N-linked (GlcNAc...); atypical.
 CARBOHYD 241 241 N-linked (GlcNAc...).
 CARBOHYD 266 266 N-linked (GlcNAc...) (Potential).
 CARBOHYD 283 283 N-linked (GlcNAc...) (Potential).
 CARBOHYD 684 684 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Direct protein sequencing; Glycoprotein; Ion transport; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 755 AA 
Protein Sequence
MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI STRQYHLQQL 60
FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS DHEHHSDHER HSDHEHHSEH 120
EHHSDHDHHS HHNHAASGKN KRKALCPDHD SDSSGKDPRN SQGKGAHRPE HASGRRNVKD 180
SVSASEVTST VYNTVSEGTH FLETIETPRP GKLFPKDVSS STPPSVTSKS RVSRLAGRKT 240
NESVSEPRKG FMYSRNTNEN PQECFNASKL LTSHGMGIQV PLNATEFNYL CPAIINQIDA 300
RSCLIHTSEK KAEIPPKTYS LQIAWVGGFI AISIISFLSL LGVILVPLMN RVFFKFLLSF 360
LVALAVGTLS GDAFLHLLPH SHASHHHSHS HEEPAMEMKR GPLFSHLSSQ NIEESAYFDS 420
TWKGLTALGG LYFMFLVEHV LTLIKQFKDK KKKNQKKPEN DDDVEIKKQL SKYESQLSTN 480
EEKVDTDDRT EGYLRADSQE PSHFDSQQPA VLEEEEVMIA HAHPQEVYNE YVPRGCKNKC 540
HSHFHDTLGQ SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA GVATLAWMVI 600
MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE LGDFAVLLKA GMTVKQAVLY 660
NALSAMLAYL GMATGIFIGH YAENVSMWIF ALTAGLFMYV ALVDMVPEML HNDASDHGCS 720
RWGYFFLQNA GMLLGFGIML LISIFEHKIV FRINF 755 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IDA:BHF-UCL.
 GO:0031258; C:lamellipodium membrane; IDA:UniProtKB.
 GO:0005385; F:zinc ion transmembrane transporter activity; IDA:BHF-UCL.
 GO:0006882; P:cellular zinc ion homeostasis; IDA:BHF-UCL.
 GO:0071578; P:zinc ion transmembrane import; IDA:BHF-UCL. 
Interpro
 IPR003689; ZIP. 
Pfam
 PF02535; Zip 
SMART
  
PROSITE
  
PRINTS