| Tag | Content |
|---|
| CPLM ID | CPLM-020002 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium/potassium/calcium exchanger 3 |
Protein Synonyms/Alias | Na(+)/K(+)/Ca(2+)-exchange protein 3 |
Gene Name | Slc24a3 |
Gene Synonyms/Alias | Nckx3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 373 | GESEVAIKIPIKHTV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity). |
Sequence Annotation | REPEAT 148 188 Alpha-1.
REPEAT 520 551 Alpha-2.
CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
CARBOHYD 85 85 N-linked (GlcNAc...) (Potential). |
Keyword | Antiport; Calcium; Calcium transport; Complete proteome; Glycoprotein; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Repeat; Signal; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 645 AA |
Protein Sequence | MPPPGDQDCA RRRSRRRRRD LLLSQLCFLA SVALLLWSLS SLREQKELDL MDLIGEDRKW 60
MVGRKLMQVN DTLTSEDAGL QSSKNCTEPA LHEFPRDIFS NEDRRQGAVV LHVLCAMYMF 120
YALAIVCDDF FVPSLEKICE RLHLSEDVAG ATFMAAGSSA PELFTSVIGV FITKGDVGVG 180
TIVGSAVFNI LCIIGVCGLF AGQVVALSSW CLLRDSIYYT LSVVALIVFI YDEKVSWWES 240
LVLVLMYLIY IVIMKYNACI HQCFERRTKG AGNMVNGLAN NAEIDDSSNC DATVVLLKKA 300
NFHRKASVIM VDELLSAYPH QLSFSEAGLR IMITSHFPPK TRLSMASRML INERQRLINS 360
RAYTNGESEV AIKIPIKHTV ENGTGPSSAP DRGVNGTRRD DIVAETDNET ENENEDNENN 420
ENDEEEEEDE DDDEGPYTPF DPPSGKLETV KWAFTWPLSF VLYFTVPNCN KPHWEKWFMV 480
TFASSTLWIA AFSYMMVWMV TIIGYTLGIP DVIMGITFLA AGTSVPDCMA SLIVARQGMG 540
DMAVSNSIGS NVFDILIGLG LPWALQTLAV DYGSYIRLNS RGLIYSVGLL LASVFVTVFG 600
VHLNKWQLDK KLGCGCLFLY GVFLCFSIMT EFNVFTFVNL PMCGD 645 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:MGI. GO:0008273; F:calcium, potassium:sodium antiporter activity; IDA:MGI. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0006874; P:cellular calcium ion homeostasis; TAS:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |