CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035665
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peripheral plasma membrane protein CASK 
Protein Synonyms/Alias
  
Gene Name
 Cask 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
95QGKLENSKNGTAGLIubiquitination[1]
168VVKLPAFKRKTLVLLacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 356 AA 
Protein Sequence
MRGSITFKIV PSYRTQSSSC ERDSPSTSRQ SPANGHSSTN NSVSIYVRAQ FEYDPAKDDL 60
IPCKEAGIRF RVGDIIQIIS KDDHNWWQGK LENSKNGTAG LIPSPELQEW RVACIAMEKT 120
KQEQQASCTW FGKKKKQYKD KYLAKHNAVF DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV 180
GRRHIKNTLI TKHPERFAYP IPHTTRPPKK DEENGKNYYF VSHDQMMQDI SNNEYLEYGS 240
HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ ALKVLRTAEF APFVVFIAAP TITPGLNEDE 300
SLQRLQKESD VLQRTYAHYF DLTIINNEID ETIRHLEEAV ELVCTAPQWV PVSWVY 356 
Gene Ontology
 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005652; C:nuclear lamina; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0070509; P:calcium ion import; IEA:Compara.
 GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Compara.
 GO:0090288; P:negative regulation of cellular response to growth factor stimulus; IEA:Compara.
 GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Compara.
 GO:0061045; P:negative regulation of wound healing; IEA:Compara.
 GO:0090280; P:positive regulation of calcium ion import; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR027417; P-loop_NTPase.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00625; Guanylate_kin
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50002; SH3 
PRINTS