UniProt Accession

 CLD3_MOUSE; Q9Z0G9; Q91X40 

Genbank Protein ID

 AF095905; AF087821; BC012650 

Genbank Nucleotide ID

 AAD14608.1; AAD09756.1; AAH12650.1 

Protein Name

 Claudin-3 

Protein Synonyms/Alias

 Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2 

Gene Name

 Cldn3 

Gene Synonyms/Alias

 Cpetr2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
194	RDKYAPTKILYSAPR	ubiquitination	[1]
216	TGTAYDRKDYV****	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. 

Sequence Annotation

 REGION 218 219 Interactions with TJP1, TJP2 and TJP3 (By
 MOD_RES 203 203 Phosphothreonine.  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 219 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005923; C:tight junction; IDA:UniProtKB.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0016338; P:calcium-independent cell-cell adhesion; IDA:UniProtKB.
 GO:0001666; P:response to hypoxia; IEA:Compara. 

Interpro

 IPR006187; Claudin.
 IPR003549; Claudin3.
 IPR017974; Claudin_CS.
 IPR004031; PMP22/EMP/MP20/Claudin. 

Pfam

 PF00822; PMP22_Claudin 

SMART

  

PROSITE

 PS01346; CLAUDIN 

PRINTS

 PR01077; CLAUDIN.
 PR01378; CLAUDIN3.