CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008353
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fragile X mental retardation syndrome-related protein 1 
Protein Synonyms/Alias
 hFXR1p 
Gene Name
 FXR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17GSNGAFYKGFIKDVHubiquitination[1]
56LPPPPDIKKEISEGDubiquitination[2, 3]
57PPPPDIKKEISEGDEubiquitination[4]
83PCGWWLAKVRMMKGEubiquitination[2, 4]
119LRPVNQNKTVKKNTFubiquitination[4]
195HLRSIRTKLMLMSRNubiquitination[4]
207SRNEEATKHLECTKQubiquitination[4]
246SNIQQARKVPGVTAIubiquitination[1, 2, 4]
273GESADAVKKARGFLEubiquitination[2, 3, 4]
274ESADAVKKARGFLEFubiquitination[4]
302KVIGKNGKVIQEIVDubiquitination[4]
310VIQEIVDKSGVVRVRubiquitination[1, 2, 4]
325IEGDNENKLPREDGMubiquitination[2, 4]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). 
Sequence Annotation
 DOMAIN 4 50 Agenet-like 1.
 DOMAIN 63 115 Agenet-like 2.
 DOMAIN 222 251 KH 1.
 DOMAIN 285 314 KH 2.
 REGION 442 457 RNA-binding RGG-box.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 68 68 Phosphotyrosine (By similarity).
 MOD_RES 406 406 Phosphoserine.
 MOD_RES 409 409 Phosphoserine.
 MOD_RES 420 420 Phosphoserine.
 MOD_RES 423 423 Phosphoserine.
 MOD_RES 485 485 Phosphoserine.
 MOD_RES 585 585 Phosphoserine (By similarity).
 MOD_RES 587 587 Phosphoserine.
 MOD_RES 611 611 Phosphothreonine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Myogenesis; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 621 AA 
Protein Sequence
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 60
EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 120
VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 180
VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 240
IQQARKVPGV TAIELDEDTG TFRIYGESAD AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 300
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 360
VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS 420
DWSLAGEDDR DSRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL 480
DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLVTVADY 540
ISRAESQSRQ RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDD ISKLQRTPGE 600
EKINTLKEEN TQEAAVLNGV S 621 
Gene Ontology
 GO:0043034; C:costamere; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; TAS:ProtInc.
 GO:0005844; C:polysome; TAS:ProtInc.
 GO:0002151; F:G-quadruplex RNA binding; IEA:Compara.
 GO:0003730; F:mRNA 3'-UTR binding; IEA:Compara.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0006915; P:apoptotic process; TAS:ProtInc.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
 GO:0017148; P:negative regulation of translation; IEA:Compara. 
Interpro
 IPR008395; Agenet-like_dom.
 IPR022034; Frag_X_MRP_fam.
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1. 
Pfam
 PF05641; Agenet
 PF12235; FXR1P_C
 PF00013; KH_1 
SMART
 SM00322; KH 
PROSITE
 PS51641; AGENET_LIKE
 PS50084; KH_TYPE_1
 PS50304; TUDOR 
PRINTS