UniProt Accession

 XBP1_HUMAN; P17861; Q8WYK6; Q969P1; Q96BD7 

Genbank Protein ID

 M31627; X55543; L13850; AB076383; AB076384; CR456611; Z93930; BC000938; BC012841; BC015709 

Genbank Nucleotide ID

 AAA36031.1; CAA39149.1; BAB82981.1; BAB82982.1; CAG30497.1; CAB45016.1; AAH00938.1; AAH12841.1; AAH15709.1 

Protein Name

 X-box-binding protein 1 

Protein Synonyms/Alias

 XBP-1; Tax-responsive element-binding protein 5 

Gene Name

 XBP1 

Gene Synonyms/Alias

 TREB5; XBP2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
262	RFDHIYTKPLVLEIP	ubiquitination	[1]
281	SQANVVVKIEEAPLS	sumoylation	[2]
302	PEFIVSVKEEPVEDD	sumoylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] SUMO modification regulates the transcriptional activity of XBP1.
 Chen H, Qi L.
 Biochem J. 2010 Jul 1;429(1):95-102. [PMID: 20408817] 

Functional Description

 Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'- GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax- responsive element (TRE) of HTLV-I. 

Sequence Annotation

 DOMAIN 70 133 bZIP.
 REGION 72 94 Basic motif (By similarity).
 REGION 98 133 Leucine-zipper (By similarity).  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0060691; P:epithelial cell maturation involved in salivary gland development; IEA:Compara.
 GO:0031017; P:exocrine pancreas development; IEA:Compara.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IMP:UniProtKB.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0051602; P:response to electrical stimulus; IEA:Compara.
 GO:0060096; P:serotonin secretion, neurotransmission; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR004827; bZIP. 

Pfam

 PF07716; bZIP_2 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS