CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012603
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2'-5'-oligoadenylate synthase-like protein 
Protein Synonyms/Alias
 2'-5'-OAS-related protein; 2'-5'-OAS-RP; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL 
Gene Name
 OASL 
Gene Synonyms/Alias
 TRIP14 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
179EVYVSLIKACGGPGNubiquitination[1]
331QRASQCLKQDCCYDNubiquitination[1]
349PISSWNVKRARDIHLubiquitination[1, 2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. 
Sequence Annotation
 DOMAIN 354 433 Ubiquitin-like 1.
 DOMAIN 434 509 Ubiquitin-like 2.  
Keyword
 3D-structure; Alternative splicing; Antiviral defense; Complete proteome; Cytoplasm; Immunity; Innate immunity; Nucleus; Polymorphism; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 514 AA 
Protein Sequence
MALMQELYST PASRLDSFVA QWLQPHREWK EEVLDAVRTV EEFLRQEHFQ GKRGLDQDVR 60
VLKVVKVGSF GNGTVLRSTR EVELVAFLSC FHSFQEAAKH HKDVLRLIWK TMWQSQDLLD 120
LGLEDLRMEQ RVPDALVFTI QTRGTAEPIT VTIVPAYRAL GPSLPNSQPP PEVYVSLIKA 180
CGGPGNFCPS FSELQRNFVK HRPTKLKSLL RLVKHWYQQY VKARSPRANL PPLYALELLT 240
IYAWEMGTEE DENFMLDEGF TTVMDLLLEY EVICIYWTKY YTLHNAIIED CVRKQLKKER 300
PIILDPADPT LNVAEGYRWD IVAQRASQCL KQDCCYDNRE NPISSWNVKR ARDIHLTVEQ 360
RGYPDFNLIV NPYEPIRKVK EKIRRTRGYS GLQRLSFQVP GSERQLLSSR CSLAKYGIFS 420
HTHIYLLETI PSEIQVFVKN PDGGSYAYAI NPNSFILGLK QQIEDQQGLP KKQQQLEFQG 480
QVLQDWLGLG IYGIQDSDTL ILSKKKGEAL FPAS 514 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0003725; F:double-stranded RNA binding; IDA:UniProtKB.
 GO:0046966; F:thyroid hormone receptor binding; TAS:UniProtKB.
 GO:0016740; F:transferase activity; IEA:InterPro.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0045071; P:negative regulation of viral genome replication; IDA:UniProtKB.
 GO:0009615; P:response to virus; IDA:UniProtKB.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 
Interpro
 IPR006117; 2-5-oligoadenylate_synth_CS.
 IPR006116; 2-5-oligoadenylate_synth_N.
 IPR018952; 2-5-oligoAdlate_synth_1_dom2/C.
 IPR026774; 2-5A_synthase.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 
Pfam
 PF10421; OAS1_C
 PF00240; ubiquitin 
SMART
 SM00213; UBQ 
PROSITE
 PS00832; 25A_SYNTH_1
 PS00833; 25A_SYNTH_2
 PS50152; 25A_SYNTH_3
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 
PRINTS