CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010935
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF23 
Protein Synonyms/Alias
 Kinesin-like protein 5; Mitotic kinesin-like protein 1 
Gene Name
 KIF23 
Gene Synonyms/Alias
 KNSL5; MKLP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MKSARAKTPRKPTVubiquitination[1]
11ARAKTPRKPTVKKGSubiquitination[1]
384NQMYGTNKMVPYRDSubiquitination[2]
503RLIEALEKRHNLRQMubiquitination[2]
523NKQSNAFKALLQEFDubiquitination[2]
566ERLEKKNKTLEYKIEubiquitination[2]
571KNKTLEYKIEILEKTubiquitination[2]
599ELETQNQKLQRQFSDubiquitination[1, 2]
624MVTETTMKWEKECERubiquitination[2]
643KQLEMQNKLWVKDEKubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. 
Sequence Annotation
 DOMAIN 1 352 Kinesin-motor.
 NP_BIND 112 119 ATP (By similarity).
 MOTIF 7 11 Nuclear localization signal (Potential).
 MOD_RES 155 155 Phosphoserine.
 MOD_RES 160 160 Phosphoserine.
 MOD_RES 605 605 Phosphoserine.
 MOD_RES 738 738 Phosphothreonine.
 MOD_RES 814 814 Phosphoserine.
 MOD_RES 867 867 Phosphoserine.
 MOD_RES 902 902 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Motor protein; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 960 AA 
Protein Sequence
MKSARAKTPR KPTVKKGSQT NLKDPVGVYC RVRPLGFPDQ ECCIEVINNT TVQLHTPEGY 60
RLNRNGDYKE TQYSFKQVFG THTTQKELFD VVANPLVNDL IHGKNGLLFT YGVTGSGKTH 120
TMTGSPGEGG LLPRCLDMIF NSIGSFQAKR YVFKSNDRNS MDIQCEVDAL LERQKREAMP 180
NPKTSSSKRQ VDPEFADMIT VQEFCKAEEV DEDSVYGVFV SYIEIYNNYI YDLLEEVPFD 240
PIKPKPPQSK LLREDKNHNM YVAGCTEVEV KSTEEAFEVF WRGQKKRRIA NTHLNRESSR 300
SHSVFNIKLV QAPLDADGDN VLQEKEQITI SQLSLVDLAG SERTNRTRAE GNRLREAGNI 360
NQSLMTLRTC MDVLRENQMY GTNKMVPYRD SKLTHLFKNY FDGEGKVRMI VCVNPKAEDY 420
EENLQVMRFA EVTQEVEVAR PVDKAICGLT PGRRYRNQPR GPVGNEPLVT DVVLQSFPPL 480
PSCEILDIND EQTLPRLIEA LEKRHNLRQM MIDEFNKQSN AFKALLQEFD NAVLSKENHM 540
QGKLNEKEKM ISGQKLEIER LEKKNKTLEY KIEILEKTTT IYEEDKRNLQ QELETQNQKL 600
QRQFSDKRRL EARLQGMVTE TTMKWEKECE RRVAAKQLEM QNKLWVKDEK LKQLKAIVTE 660
PKTEKPERPS RERDREKVTQ RSVSPSPVPL LFQPDQNAPP IRLRHRRSRS AGDRWVDHKP 720
ASNMQTETVM QPHVPHAITV SVANEKALAK CEKYMLTHQE LASDGEIETK LIKGDIYKTR 780
GGGQSVQFTD IETLKQESPN GSRKRRSSTV APAQPDGAES EWTDVETRCS VAVEMRAGSQ 840
LGPGYQHHAQ PKRKKP 856 
Gene Ontology
 GO:0097149; C:centralspindlin complex; IDA:UniProtKB.
 GO:0005813; C:centrosome; IDA:MGI.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0045171; C:intercellular bridge; IEA:Compara.
 GO:0005871; C:kinesin complex; TAS:ProtInc.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008017; F:microtubule binding; IDA:UniProtKB.
 GO:0003777; F:microtubule motor activity; TAS:ProtInc.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0000910; P:cytokinesis; IMP:UniProtKB.
 GO:0007018; P:microtubule-based movement; TAS:Reactome.
 GO:0000022; P:mitotic spindle elongation; TAS:ProtInc.
 GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
 GO:0051256; P:spindle midzone assembly involved in mitosis; IMP:UniProtKB. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.