UniProt Accession

 MANF_RAT; P0C5H9 

Genbank Protein ID

 AABR03063460 

Genbank Nucleotide ID

  

Protein Name

 Mesencephalic astrocyte-derived neurotrophic factor 

Protein Synonyms/Alias

 Arginine-rich protein; Protein ARMET 

Gene Name

 Manf 

Gene Synonyms/Alias

 Armet 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
42	GRFYQDLKDRDVTFS	acetylation	[1]
91	KIINEVSKPLAHHIP	acetylation	[1]
117	DSQICELKYDKQIDL	acetylation	[1]
120	ICELKYDKQIDLSTV	acetylation	[1]
130	DLSTVDLKKLRVKEL	acetylation	[1]
167	KINELMPKYAPKAAS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. 

Sequence Annotation

 MOD_RES 73 73 Phosphotyrosine (By similarity).
 DISULFID 27 114 By similarity.
 DISULFID 30 103 By similarity.
 DISULFID 61 72 By similarity.
 DISULFID 148 151 By similarity.  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Growth factor; Phosphoprotein; Reference proteome; Secreted; Signal; Unfolded protein response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
 GO:0002014; P:vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure; IEA:Compara. 

Interpro

 IPR019345; Armet_prot.
 IPR011001; Saposin-like. 

Pfam

 PF10208; Armet 

SMART

  

PROSITE

  

PRINTS