CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002305
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin light chain 1/3, skeletal muscle isoform 
Protein Synonyms/Alias
 MLC1/MLC3; MLC1F/MLC3F; Myosin light chain alkali 1/2; Myosin light chain A1/A2 
Gene Name
 Myl1 
Gene Synonyms/Alias
 Mylf 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
8MAPKKDVKKPAAAPAubiquitination[1]
9APKKDVKKPAAAPAPubiquitination[1]
26APAPAPAKPKEEKIDubiquitination[1]
28APAPAKPKEEKIDLSubiquitination[1]
31PAKPKEEKIDLSAIKubiquitination[1]
38KIDLSAIKIEFSKEQubiquitination[1]
43AIKIEFSKEQQEDFKubiquitination[1]
50KEQQEDFKEAFLLFDubiquitination[1]
63FDRTGECKITLSQVGubiquitination[1]
86NPTNAEVKKVLGNPSubiquitination[1]
87PTNAEVKKVLGNPSNubiquitination[1]
100SNEEMNAKKIEFEQFubiquitination[1]
101NEEMNAKKIEFEQFLubiquitination[1]
135EGLRVFDKEGNGTVMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Regulatory light chain of myosin. Does not bind calcium. 
Sequence Annotation
 DOMAIN 44 79 EF-hand 1.
 DOMAIN 121 156 EF-hand 2.
 DOMAIN 156 188 EF-hand 3.
 MOD_RES 2 2 N,N,N-trimethylalanine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Methylation; Motor protein; Muscle protein; Myosin; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 188 AA 
Protein Sequence
MAPKKDVKKP AAAPAPAPAP APAPAKPKEE KIDLSAIKIE FSKEQQEDFK EAFLLFDRTG 60
ECKITLSQVG DVLRALGTNP TNAEVKKVLG NPSNEEMNAK KIEFEQFLPM MQAISNNKDQ 120
GGYEDFVEGL RVFDKEGNGT VMGAELRHVL ATLGEKMKEE EVEALLAGQE DSNGCINYEA 180
FVKHIMSV 188 
Gene Ontology
 GO:0030016; C:myofibril; IEA:Compara.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom. 
Pfam
 PF13405; EF_hand_4 
SMART
 SM00054; EFh 
PROSITE
 PS50222; EF_HAND_2 
PRINTS