UniProt Accession

 SARNP_HUMAN; P82979; A8K393; Q9P066 

Genbank Protein ID

 AJ409089; AF486281; AF161434; AK290508; CH471054; BC007099 

Genbank Nucleotide ID

 CAC37950.1; AAM09686.1; AAF28994.1; BAF83197.1; EAW96838.1; AAH07099.1 

Protein Name

 SAP domain-containing ribonucleoprotein 

Protein Synonyms/Alias

 Cytokine-induced protein of 29 kDa; Nuclear protein Hcc-1; Proliferation-associated cytokine-inducible protein CIP29 

Gene Name

 SARNP 

Gene Synonyms/Alias

 HCC1; HSPC316 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	TETVELHKLKLAELK	ubiquitination	[1, 2]
92	AAEKKVVKITSEIPQ	ubiquitination	[1, 2]
135	GISSVPTKGLSSDNK	ubiquitination	[1, 2]
142	KGLSSDNKPMVNLDK	acetylation	[3]
199	TTEDTEAKKRKRAER	ubiquitination	[4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. 

Sequence Annotation

 DOMAIN 8 42 SAP.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 163 163 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transcription; Transcription regulation; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 210 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; NAS:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003034; SAP_dom. 

Pfam

 PF02037; SAP 

SMART

 SM00513; SAP 

PROSITE

 PS50800; SAP 

PRINTS