UniProt Accession

 DRE2_YEAST; P36152; D6VXD2 

Genbank Protein ID

 Z28296; BK006944 

Genbank Nucleotide ID

 CAA82150.1; DAA09222.1 

Protein Name

 Fe-S cluster assembly protein DRE2 

Protein Synonyms/Alias

 Anamorsin homolog 

Gene Name

 DRE2 

Gene Synonyms/Alias

 YKR071C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
188	SFKPPSFKMTTEPKV	ubiquitination	[1]
271	KDCTCGMKEQEENEI	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins (By similarity). Has anti- apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death, probably by tethering the pro- apoptotic factor TAH18 in the cytoplasm in the absence of oxidative stress (By similarity). 

Sequence Annotation

 MOD_RES 206 206 Phosphoserine.  

Keyword

 2Fe-2S; 3D-structure; 4Fe-4S; Apoptosis; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Mitochondrion; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 348 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
 GO:0005634; C:nucleus; IEA:HAMAP.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IDA:UniProtKB.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
 GO:0009055; F:electron carrier activity; IMP:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0010421; P:hydrogen peroxide-mediated programmed cell death; IEA:HAMAP.
 GO:0016226; P:iron-sulfur cluster assembly; IMP:SGD.
 GO:0043066; P:negative regulation of apoptotic process; IEA:HAMAP. 

Interpro

 IPR007785; Anamorsin. 

Pfam

 PF05093; CIAPIN1 

SMART

  

PROSITE

  

PRINTS