UniProt Accession

 PVRL3_MOUSE; Q9JLB9; Q059N7; Q9D006; Q9JLB7; Q9JLB8 

Genbank Protein ID

 AF195833; AF195834; AF195835; AK011949; BC125588; BC132187 

Genbank Nucleotide ID

 AAF63685.1; AAF63686.1; AAF63687.1; BAB27933.1; AAI25589.1; AAI32188.1 

Protein Name

 Poliovirus receptor-related protein 3 

Protein Synonyms/Alias

 Nectin-3; CD113 

Gene Name

 Pvrl3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
451	IPPSDMQKESQIDVL	ubiquitination	[1]
471	DSYPDSVKKENKNPV	ubiquitination	[1]
475	DSVKKENKNPVNNLI	ubiquitination	[1]
484	PVNNLIRKDYLEEPE	ubiquitination	[1]
492	DYLEEPEKTQWNNVE	ubiquitination	[1]
515	MDYYEDLKMGMKFVS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. 

Sequence Annotation

 DOMAIN 58 165 Ig-like V-type.
 DOMAIN 170 258 Ig-like C2-type 1.
 DOMAIN 269 354 Ig-like C2-type 2.
 MOD_RES 529 529 Phosphoserine.
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
 CARBOHYD 125 125 N-linked (GlcNAc...) (Potential).
 CARBOHYD 186 186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 222 222 N-linked (GlcNAc...) (Potential).
 CARBOHYD 331 331 N-linked (GlcNAc...) (Potential).
 DISULFID 78 148 By similarity.
 DISULFID 193 246 By similarity.
 DISULFID 291 338 By similarity.  

Keyword

 Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 549 AA 

Protein Sequence

Gene Ontology

 GO:0043296; C:apical junction complex; IDA:MGI.
 GO:0005913; C:cell-cell adherens junction; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:HGNC.
 GO:0042803; F:protein homodimerization activity; IDA:HGNC.
 GO:0009566; P:fertilization; IMP:MGI.
 GO:0007156; P:homophilic cell adhesion; IDA:HGNC.
 GO:0002089; P:lens morphogenesis in camera-type eye; IMP:MGI.
 GO:0060042; P:retina morphogenesis in camera-type eye; IMP:MGI. 

Interpro

 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 

Pfam

 PF08205; C2-set_2
 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS