| Tag | Content |
|---|
| CPLM ID | CPLM-016794 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 UFM1-protein ligase 1 |
Protein Synonyms/Alias | |
Gene Name | Ufl1 |
Gene Synonyms/Alias | Kiaa0776 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 558 | RLFEKGMKYFADDTQ | ubiquitination | [1] | | 570 | DTQTALTKHLLKTVC | ubiquitination | [1] | | 624 | ETKVALTKLHNSLNE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1. The function of ufmylation is unknown (By similarity). May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3 (By similarity). |
Sequence Annotation | REGION 1 212 Required for E3 UFM1-protein ligase
MOD_RES 458 458 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Endoplasmic reticulum; Ligase; Phosphoprotein; Reference proteome; Tumor suppressor; Ubl conjugation; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 793 AA |
Protein Sequence | MADAWEEIRR LAADFQRAQF AESTQRLSER NCIEIVNKLI SQKQLEVVHT LDGKEYITPA 60
QISKEMRDEL HVRGGRVNIV DLQQVINVDL THIESRVSDI IKSEKHVQMV LGQLIDENYL 120
DQLSEEVNDK LQESGQVTVS ELCKAYDLPG DFLTQALTQR LGRIINGHLD LDNRGVIFTE 180
AFVARHKARI RGLFSAITRP TPVNSLVSKY GFQEQLLYSV LEDLVSTGRL RGTVVGGRQD 240
KAVFVPDIYS RTQSTWVDSF FRQNGYLEFD ALSRLGIPDA VNYIKKRYKN TQLLFLKATC 300
VGQGLVDQVE ASVEEAISSG TWVDISPLLP SSLSVEDAAM LLQQVMRPFG KLASAIVFSD 360
TVVVSEKFIT DCTGLFSERM HQKAEKEMKN NPVHLITEED LKQISILESV NTSKKDKKDE 420
RRKKATEGSG SVRGGGGGNA REYKIKKTKK KGRKDEDSDD ESQSSHGGKK KPDITFMFQD 480
EIEDCLRKHI QDAPEEFISE LAEYLIKPLN KMYLEVVRSV FMSSTSASGT GRKRTIKDLQ 540
EEVSNLYNNI RLFEKGMKYF ADDTQTALTK HLLKTVCTDI TNLMFNFLAS DFLMAVEEPA 600
AITSDIRKKI LSKLTEETKV ALTKLHNSLN EKSIEDFLSC LDSATEACDI MVKKGDKKRE 660
RQILFQHRQA LCEQLKVTED PALILHLTAV LLFQLSTHSM LHAPGRCVPQ IIAFLHSKIP 720
EDQHTLLVKY QGLVVKQLVS QNKKTGQGED PSSDELDKEQ HDVTNATRKE LQELSLSIKD 780
LVLKSRKSSV TEE 793 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. GO:0005634; C:nucleus; IEA:Compara. GO:0071568; F:UFM1 conjugating enzyme activity; ISS:UniProtKB. GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB. GO:0071569; P:protein ufmylation; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |