CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013928
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger MYM-type protein 1 
Protein Synonyms/Alias
  
Gene Name
 ZMYM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25LGLLDEIKTEPDNAQsumoylation[1]
25LGLLDEIKTEPDNAQubiquitination[2]
94VSCAGCKKILQKGQTubiquitination[2]
98GCKKILQKGQTAYQRubiquitination[2]
521EKSEMHLKSLEFWREubiquitination[3, 4]
551SKQIEGNKKYLKLIIubiquitination[4]
552KQIEGNKKYLKLIIEubiquitination[2]
671RYPQKSSKAILIKERubiquitination[2, 3, 4]
676SSKAILIKERFLGFVubiquitination[2]
698THLHRTIKTYLQQIGubiquitination[3]
926ICQKITCKGFKVEKPacetylation[5]
943QKRRKIQKSVDLGNSubiquitination[3]
1018KHVQEFYKLDEDIIPubiquitination[3]
1094FSTLPRLKTYLCNTMubiquitination[2]
1140EKFISQMKEI*****ubiquitination[2, 3]
Reference
 [1] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786
Functional Description
  
Sequence Annotation
 ZN_FING 110 148 MYM-type 1.
 ZN_FING 160 203 MYM-type 2.
 ZN_FING 210 245 MYM-type 3.
 ZN_FING 300 331 MYM-type 4.
 ZN_FING 452 538 TTF-type.  
Keyword
 Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1142 AA 
Protein Sequence
MKEPLLGGEC DKAVASQLGL LDEIKTEPDN AQEYCHRQQS RTQENELKIN AVFSESASQL 60
TAGIQLSLAS SGVNKMLPSV STTAIQVSCA GCKKILQKGQ TAYQRKGSAQ LFCSIPCITE 120
YISSASSPVP SKRTCSNCSK DILNPKDVIS VQLEDTTSCK TFCSLSCLSS YEEKRKPFVT 180
ICTNSILTKC SMCQKTAIIQ YEVKYQNVKH NLCSNACLSK FHSANNFIMN CCENCGTYCY 240
TSSSLSHILQ MEGQSHYFNS SKSITAYKQK PAKPLISVPC KPLKPSDEMI ETTSDLGKTE 300
LFCSINCFSA YSKAKMESSS VSVVSVVHDT STELLSPKKD TTPVISNIVS LADTDVALPI 360
MNTDVLQDTV SSVTATADVI VDLSKSSPSE PSNAVASSST EQPSVSPSSS VFSQHAIGSS 420
TEVQKDNMKS MKISDELCHP KCTSKVQKVK GKSRSIKKSC CADFECLENS KKDVAFCYSC 480
QLFCQKYFSC GRESFATHGT SNWKKTLEKF RKHEKSEMHL KSLEFWREYQ FCDGAVSDDL 540
SIHSKQIEGN KKYLKLIIEN ILFLGKQCLP LRGNDQSVSS VNKGNFLELL EMRAKDKGEE 600
TFRLMNSQVD FYNSTQIQSD IIEIIKTEML QDIVNEINDS SAFSIICDET INSAMKEQLS 660
ICVRYPQKSS KAILIKERFL GFVDTEEMTG THLHRTIKTY LQQIGVDMDK IHGQAYDSTT 720
NLKIKFNKIA AEFKKEEPRA LYIHCYAHFL DLSIIRFCKE VKELRSALKT LSSLFNTICM 780
SGEMLANFRN IYRLSQNKTC KKHISQSCWT VHDRTLLSVI DSLPEIIETL EVIASHSSNT 840
SFADELSHLL TLVSKFEFVF CLKFLYRVLS VTGILSKELQ NKTIDIFSLS SKIEAILECL 900
SSERNDVYFK TIWDGTEEIC QKITCKGFKV EKPSLQKRRK IQKSVDLGNS DNMFFPTSTE 960
EQYKINIYYQ GLDTILQNLK LCFSEFDYCK IKQISELLFK WNEPLNETTA KHVQEFYKLD 1020
EDIIPELRFY RHYAKLNFVI DDSCINFVSL GCLFIQHGLH SNIPCLSKLL YIALSWPITS 1080
ASTENSFSTL PRLKTYLCNT MGQEKLTGPA LMAVEQELVN KLMEPERLNE IVEKFISQMK 1140
EI 1142 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR025398; DUF4371.
 IPR008906; HATC.
 IPR012337; RNaseH-like_dom.
 IPR011017; TRASH_dom.
 IPR010507; Znf_MYM.
 IPR006580; Znf_TTF. 
Pfam
 PF05699; Dimer_Tnp_hAT
 PF14291; DUF4371
 PF06467; zf-FCS 
SMART
 SM00746; TRASH
 SM00597; ZnF_TTF 
PROSITE
  
PRINTS