CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033086
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prostate leucine zipper variant 2 
Protein Synonyms/Alias
 Tumor protein D52 
Gene Name
 TPD52 
Gene Synonyms/Alias
 PrLZ 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
100LSQVLAAKEKHLAEIacetylation[1]
100LSQVLAAKEKHLAEIubiquitination[2, 3, 4, 5, 6, 7, 8]
102QVLAAKEKHLAEIKRubiquitination[6, 8]
120INSLQELKQNIAKGWubiquitination[3, 7, 8]
125ELKQNIAKGWQDVTAubiquitination[2]
137VTATSAYKKTSETLSubiquitination[2]
138TATSAYKKTSETLSQubiquitination[3, 6, 7, 8]
149TLSQAGQKASAAFSSubiquitination[3, 6, 8]
194TFKSFEEKVENLKSKubiquitination[3, 6, 8]
201KVENLKSKVGGTKPAubiquitination[3, 8]
206KSKVGGTKPAGGDFGubiquitination[3]
233TTEPLPEKTQESL**ubiquitination[3, 7]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [8] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 238 AA 
Protein Sequence
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR TDPVPEEGED 60
VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK EKHLAEIKRK LGINSLQELK 120
QNIAKGWQDV TATSAYKKTS ETLSQAGQKA SAAFSSVGSV ITKKLEDVNI RSIQHSISMP 180
AMRNSPTFKS FEEKVENLKS KVGGTKPAGG DFGEVLNSAA NASATTTEPL PEKTQESL 238 
Gene Ontology
  
Interpro
 IPR007327; TPD52. 
Pfam
 PF04201; TPD52 
SMART
  
PROSITE
  
PRINTS