UniProt Accession

 STXB1_MOUSE; O08599; A2ARS2; A2ARS3; A2ARS4; Q5WAC6; Q8VD51 

Genbank Protein ID

 D45903; AB012697; AF326545; AF326563; AL845471; AL845471; AL845471; BC031728 

Genbank Nucleotide ID

 BAA19479.1; BAA32486.1; AAL37391.1; AAL37409.1; CAM20726.1; CAM20727.1; CAM20728.1; AAH31728.1 

Protein Name

 Syntaxin-binding protein 1 

Protein Synonyms/Alias

 Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A 

Gene Name

 Stxbp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	LKAVVGEKIMHDVIK	ubiquitination	[1]
92	HSLISDFKDPPTAKY	ubiquitination	[1]
120	ALFNELVKSRAAKVI	ubiquitination	[1]
184	ATLCATLKEYPAVRY	ubiquitination	[1]
196	VRYRGEYKDNALLAQ	ubiquitination	[1]
208	LAQLIQDKLDAYKAD	ubiquitination	[1]
225	TMGEGPDKARSQLLI	ubiquitination	[1]
294	LWIALRHKHIAEVSQ	ubiquitination	[1]
308	QEVTRSLKDFSSSKR	ubiquitination	[1]
364	HYQGTVDKLCRVEQD	ubiquitination	[1]
382	GTDAEGEKIKDPMRA	ubiquitination	[1]
483	SRWTPIIKDIMEDTI	ubiquitination	[1]
497	IEDKLDTKHYPYIST	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity). 

Sequence Annotation

 MOD_RES 107 107 Phosphothreonine.
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 145 145 Phosphotyrosine.
 MOD_RES 146 146 Phosphoserine.
 MOD_RES 345 345 Phosphoserine.
 MOD_RES 346 346 Phosphothreonine.
 MOD_RES 473 473 Phosphotyrosine.
 MOD_RES 507 507 Phosphoserine.
 MOD_RES 509 509 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 594 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0031091; C:platelet alpha granule; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0017075; F:syntaxin-1 binding; ISO:MGI.
 GO:0007412; P:axon target recognition; IMP:MGI.
 GO:0060292; P:long term synaptic depression; IMP:MGI.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
 GO:0032229; P:negative regulation of synaptic transmission, GABAergic; IDA:MGI.
 GO:0007274; P:neuromuscular synaptic transmission; IMP:MGI.
 GO:0007269; P:neurotransmitter secretion; IMP:MGI.
 GO:0070527; P:platelet aggregation; IEA:Compara.
 GO:0002576; P:platelet degranulation; IEA:Compara.
 GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IDA:MGI.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0010807; P:regulation of synaptic vesicle priming; IEA:Compara.
 GO:0016188; P:synaptic vesicle maturation; IMP:MGI.
 GO:0006904; P:vesicle docking involved in exocytosis; IMP:MGI. 

Interpro

 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 

Pfam

 PF00995; Sec1 

SMART

  

PROSITE

  

PRINTS