CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020911
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Amyloid protein-binding protein 2 
Protein Synonyms/Alias
 Amyloid beta precursor protein-binding protein 2; APP-BP2 
Gene Name
 Appbp2 
Gene Synonyms/Alias
 Kiaa0228 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
522YDYRGLIKLYNSIGNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface (By similarity). 
Sequence Annotation
 REPEAT 50 83 TPR 1.
 REPEAT 120 153 TPR 2.
 REPEAT 206 239 TPR 3.
 REPEAT 288 321 TPR 4.
 REPEAT 333 367 TPR 5.
 REPEAT 429 462 TPR 6.
 REPEAT 471 505 TPR 7.
 REPEAT 514 547 TPR 8.  
Keyword
 Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Microtubule; Nucleus; Protein transport; Reference proteome; Repeat; TPR repeat; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 585 AA 
Protein Sequence
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ GRLCQLGSEF 60
CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS FSRRCSYIAE SDAAVKEKAI 120
QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC TLHDEMLHWF RAVECCVRLL HVRNGNCKYH 180
LGEETFKLAQ TYMDKLSKHG QQANRAALYG ELCALLFAKS HYDEAYKWCV EAMKEITAGL 240
PVKVVVDVLR QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN 300
VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF DNALFHAERA 360
IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ RLLQEAHDLH LSSLQLAKKA 420
FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE MHIKAIQIKE QLLGQEDYEV ALSVGHLASL 480
YNYDMNQYEN AEKLYLRSIA IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL 540
SNWNRLRDRQ YSVTDALEDV SSSPQSTEEV VQSFLMAQNV EGPSC 585 
Gene Ontology
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:Compara.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0046907; P:intracellular transport; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
  
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS