UniProt Accession

 GAMT_HUMAN; Q14353; A8K0A0; Q53Y34; Q8WVJ1 

Genbank Protein ID

 Z49878; AF010248; AF010246; AF010247; AF188893; BT007034; AK289465; AC005329; CH471139; BC016760; BC017936 

Genbank Nucleotide ID

 CAA90035.1; AAD04781.1; AAD04781.1; AAD04781.1; AAF01461.1; AAP35682.1; BAF82154.1; AAC27668.1; EAW69505.1; AAH16760.1; AAH17936.1 

Protein Name

 Guanidinoacetate N-methyltransferase 

Protein Synonyms/Alias

  

Gene Name

 GAMT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
39	THLRILGKPVMERWE	ubiquitination	[1]
60	LAAAASSKGGRVLEV	ubiquitination	[1]
235	MITPLVTKG******	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

 DOMAIN 13 236 RMT2.
 REGION 69 74 S-adenosyl-L-methionine binding.
 REGION 90 92 S-adenosyl-L-methionine.
 REGION 117 118 S-adenosyl-L-methionine binding.
 REGION 171 172 Substrate binding.
 BINDING 20 20 S-adenosyl-L-methionine.
 BINDING 42 42 Substrate (By similarity).
 BINDING 46 46 Substrate (By similarity).
 BINDING 50 50 S-adenosyl-L-methionine.
 BINDING 135 135 S-adenosyl-L-methionine and substrate (By  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Disease mutation; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030731; F:guanidinoacetate N-methyltransferase activity; IMP:UniProtKB.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006601; P:creatine biosynthetic process; IDA:UniProtKB.
 GO:0006936; P:muscle contraction; TAS:ProtInc.
 GO:0009887; P:organ morphogenesis; IEA:Compara.
 GO:0040014; P:regulation of multicellular organism growth; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR016550; GuanidinoAc_N-MeTrfase.
 IPR026480; RMT2_dom. 

Pfam

  

SMART

  

PROSITE

 PS51559; SAM_RMT2 

PRINTS