UniProt Accession

 A2ARF6_MOUSE; A2ARF6 

Genbank Protein ID

 AL845364 

Genbank Nucleotide ID

  

Protein Name

 GTP:AMP phosphotransferase AK4, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Ak4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
45	HLLRENLKTGTEVGD	acetylation	[1]
45	HLLRENLKTGTEVGD	succinylation	[1]
60	VAKQYLEKGLLVPDH	acetylation	[1, 2]
60	VAKQYLEKGLLVPDH	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 115 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0046899; F:nucleoside triphosphate adenylate kinase activity; IEA:Compara.
 GO:0046033; P:AMP metabolic process; IEA:Compara.
 GO:0046034; P:ATP metabolic process; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0018885; P:carbon tetrachloride metabolic process; IEA:Compara.
 GO:0046039; P:GTP metabolic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043643; P:tetracycline metabolic process; IEA:Compara. 

Interpro

 IPR000850; Adenylate_kin.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.