CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044336
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sentrin-specific protease 3 
Protein Synonyms/Alias
  
Gene Name
 SENP3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43PPPKPRLKSGGGFGPubiquitination[1, 2, 3, 4]
231DGLRWTPKSPLDPDSubiquitination[3, 4]
357EFSTPSRKGLVLQLIubiquitination[3]
445DGVKRWTKNVDIFNKubiquitination[1, 3, 4]
496RCPKHIAKYLQAEAVubiquitination[3]
504YLQAEAVKKDRLDFHubiquitination[3]
505LQAEAVKKDRLDFHQubiquitination[3]
515LDFHQGWKGYFKMNVubiquitination[3]
519QGWKGYFKMNVARQNubiquitination[3]
540AFVLQYCKHLALSQPubiquitination[3]
557FTQQDMPKLRRQIYKubiquitination[3]
564KLRRQIYKELCHCKLubiquitination[3]
570YKELCHCKLTV****ubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 573 AA 
Protein Sequence
MKETIQGTGS WGPEPPGPGI PPAYSSPRRE RLRWPPPPKP RLKSGGGFGP DPGSGTTVPA 60
RRLPVPRPSF DASASEEEEE EEEEEDEDEE EEVAAWRLPP RWSQLGTSQR PRPSRPTHRK 120
TCSQRRRRAM RAFRMLLYSK STSLTFHWKL WGRHRGRRRG LAHPKNHLSP QQGGATPQVP 180
SPCCRFDSPR GPPPPRLGLL GALMAEDGVR GSPPVPSGPP MEEDGLRWTP KSPLDPDSGL 240
LSCTLPNGFG GQSGPEGERS LAPPDASILI SNVCSIGDHV AQELFQGSDL GMAEEAERPG 300
EKAGQHSPLR EEHVTCVQSI LDEFLQTYGS LIPLSTDEVV EKLEDIFQQE FSTPSRKGLV 360
LQLIQSYQRM PGNAMVRGFR VAYKRHVLTM DDLGTLYGQN WLNDQVMNMY GDLVMDTVPE 420
KVHFFNSFFY DKLRTGYDGV KRWTKNVDIF NKELLLIPIH LEVHWSLISV DVRRRTITYF 480
DSQRTLNRRC PKHIAKYLQA EAVKKDRLDF HQGWKGYFKM NVARQNNDSD CGAFVLQYCK 540
HLALSQPFSF TQQDMPKLRR QIYKELCHCK LTV 573 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR003653; Peptidase_C48. 
Pfam
 PF02902; Peptidase_C48 
SMART
  
PROSITE
 PS50600; ULP_PROTEASE 
PRINTS