| Tag | Content |
|---|
| CPLM ID | CPLM-011911 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-globin transcription factor CP2 |
Protein Synonyms/Alias | SAA3 enhancer factor; Transcription factor LSF |
Gene Name | TFCP2 |
Gene Synonyms/Alias | LSF; SEF |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 104 | IRMLDNRKLGELPEI | ubiquitination | [1] | | 181 | EFLWDPAKRTSVFIQ | ubiquitination | [1] | | 217 | RVQIDTFKENENGEY | ubiquitination | [1] | | 359 | FSGADLLKLTRDDVI | ubiquitination | [1] | | 382 | IRLFNALKGRMVRPR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. |
Sequence Annotation | REGION 133 395 DNA-binding. |
Keyword | Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 502 AA |
Protein Sequence | MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK QEESSLPPDN 60
ENKILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML DNRKLGELPE INGKLVKSIF 120
RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL DIDIPMSVGI IDPRANPTQL NTVEFLWDPA 180
KRTSVFIQVH CISTEFTMRK HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP 240
KGADRKQKTD REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNSP SPGFNSSHSS 300
FSLGEGNGSP NHQPEPPPPV TDNLLPTTTP QEAQQWLHRN RFSTFTRLFT NFSGADLLKL 360
TRDDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESLQ LREQQQQQQQ QQQKHEDGDS 420
NGTFFVYHAI YLEELTAVEL TEKIAQLFSI SPCQISQIYK QGPTGIHVLI SDEMIQNFQE 480
EACFILDTMK AETNDSYHII LK 502 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; TAS:ProtInc. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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