UniProt Accession

 DSBC_ECOLI; P0AEG6; P21892; Q2M9U8 

Genbank Protein ID

 M54884; U28375; U00096; AP009048 

Genbank Nucleotide ID

 AAA62788.1; AAA83074.1; AAC75931.1; BAE76958.1 

Protein Name

 Thiol:disulfide interchange protein DsbC 

Protein Synonyms/Alias

  

Gene Name

 dsbC 

Gene Synonyms/Alias

 xprA; b2893; JW2861 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
85	APVNVTNKMLLKQLN	acetylation	[1]
89	VTNKMLLKQLNALEK	acetylation	[1]
231	EFLDEHQKMTSGK**	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD. 

Sequence Annotation

 DOMAIN 36 231 Thioredoxin.
 DISULFID 118 121 Redox-active.
 DISULFID 161 183  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Periplasm; Redox-active center; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0030288; C:outer membrane-bounded periplasmic space; NAS:EcoliWiki.
 GO:0003756; F:protein disulfide isomerase activity; IDA:EcoCyc.
 GO:0015035; F:protein disulfide oxidoreductase activity; IMP:UniProtKB.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 

Interpro

 IPR018950; DiS-bond_isomerase_DsbC/G_N.
 IPR009094; DiS-bond_isomerase_DsbC_N.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS. 

Pfam

 PF10411; DsbC_N
 PF13098; Thioredoxin_2 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS