UniProt Accession

 PACRG_HUMAN; Q96M98; E1P5B5; Q6IMB8; Q8IZM1; Q8NHP5; Q9H1V9 

Genbank Protein ID

 AF546872; AK057286; AL354942; AL031121; AL137182; AP001576; AL137182; AL031121; AL354942; AP001576; AL031121; AL137182; AL354942; AP001576; AL078585; AL590286; AL603788; CH471051; CH471051; BC030642; BC044227; BK001670 

Genbank Nucleotide ID

 AAN37911.1; BAB71410.1; CAI16054.1; CAI16054.1; CAI16054.1; CAI16054.1; CAI19951.1; CAI19951.1; CAI19951.1; CAI19951.1; CAI21557.1; CAI21557.1; CAI21557.1; CAI21557.1; EAW47565.1; EAW47566.1; AAH30642.1; AAH44227.1; DAA02134.1 

Protein Name

 Parkin coregulated gene protein 

Protein Synonyms/Alias

 Molecular chaperone/chaperonin-binding protein; PARK2 coregulated gene protein 

Gene Name

 PACRG 

Gene Synonyms/Alias

 GLUP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
68	AFKERPTKPTAFRKF	ubiquitination	[1, 2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 296 AA 

Protein Sequence

Gene Ontology

 GO:0044297; C:cell body; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0097225; C:sperm midpiece; IEA:Compara.
 GO:0007286; P:spermatid development; IEA:Compara. 

Interpro

 IPR019399; Parkin_co-regulated_protein. 

Pfam

 PF10274; ParcG 

SMART

  

PROSITE

  

PRINTS