CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016907
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 2D26 
Protein Synonyms/Alias
 CYPIID26 
Gene Name
 Cyp2d26 
Gene Synonyms/Alias
 Cyp2d-26 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
118NHIGYGHKSKGVILAubiquitination[1]
120IGYGHKSKGVILAPYubiquitination[1]
284AFLAEVEKAKGNPESubiquitination[1]
286LAEVEKAKGNPESSFubiquitination[1]
296PESSFNDKNLRIVVIubiquitination[1]
386HMTSRDIKFQDFFIPacetylation[2, 3, 4]
386HMTSRDIKFQDFFIPubiquitination[1]
407PNLSSVLKDETVWEKubiquitination[1]
414KDETVWEKPLRFYPEubiquitination[1]
432DAQGHFVKHEAFMPFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (By similarity). 
Sequence Annotation
 METAL 446 446 Iron (heme axial ligand).
 MOD_RES 138 138 Phosphoserine.  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MGLLVGDDLW AVVIFTAIFL LLVDLVHRRQ RWTACYPPGP VPFPGLGNLL QVDFENIPYS 60
FYKLQNRYGN VFSLQMAWKP VVVVNGLKAV RELLVTYGED TSDRPLMPIY NHIGYGHKSK 120
GVILAPYGPE WREQRRFSVS TLRDFGLGKK SLEQWVTEEA GHLCDAFTKE AEHPFNPSPL 180
LSKAVSNVIA SLIYARRFEY EDPFFNRMLK TLKESLGEDT GFVGEVLNAI PMLLHIPGLP 240
DKAFPKLNSF IALVNKMLIE HDLTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDKNLRI 300
VVIDLFMAGM VTTSTTLSWA LLLMILHPDV QRRVHQEIDE VIGHVRHPEM ADQARMPYTN 360
AVIHEVQRFA DIVPTNLPHM TSRDIKFQDF FIPKGTTLIP NLSSVLKDET VWEKPLRFYP 420
EHFLDAQGHF VKHEAFMPFS AGRRSCLGEP LARMELFLFF TCLLQRFSFS VPDGQPRPSD 480
YGIYTMPVTP EPYQLCAVAR 500 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008069; Cyt_P450_E_grp-I_CYP2D-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01686; EP450ICYP2D.
 PR00385; P450.