UniProt Accession

 SAHH_MYCTU; P60176; L0TBZ4; O08364; P81858 

Genbank Protein ID

 AE000516; AL123456 

Genbank Nucleotide ID

 AAK47688.1; CCP46067.1 

Protein Name

 Adenosylhomocysteinase 

Protein Synonyms/Alias

 S-adenosyl-L-homocysteine hydrolase; AdoHcyase 

Gene Name

 ahcY 

Gene Synonyms/Alias

 sahH; Rv3248c; MT3346; MTCY20B11.23c 

Created Date

 July 27, 2013 

Organism

 Mycobacterium tuberculosis 

NCBI Taxa ID

 1773 

Lysine Modification

Position	Peptide	Type	References
474	GHLTKLTKEQAEYLG	pupylation	[1]

Reference

 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036] 

Functional Description

 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity). 

Sequence Annotation

 NP_BIND 219 221 NAD (By similarity).
 NP_BIND 282 287 NAD (By similarity).
 NP_BIND 361 363 NAD (By similarity).
 BINDING 71 71 Substrate (By similarity).
 BINDING 156 156 Substrate (By similarity).
 BINDING 218 218 Substrate (By similarity).
 BINDING 248 248 Substrate (By similarity).
 BINDING 252 252 Substrate (By similarity).
 BINDING 253 253 NAD (By similarity).
 BINDING 305 305 NAD (By similarity).
 BINDING 340 340 NAD (By similarity).
 BINDING 409 409 NAD (By similarity).
 CROSSLNK 474 474 Isoglutamyl lysine isopeptide (Lys-Gln)  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Isopeptide bond; NAD; One-carbon metabolism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 495 AA 

Protein Sequence

Gene Ontology

 GO:0005618; C:cell wall; IDA:MTBBASE.
 GO:0005829; C:cytosol; IDA:MTBBASE.
 GO:0005576; C:extracellular region; IDA:MTBBASE.
 GO:0005886; C:plasma membrane; IDA:MTBBASE.
 GO:0004013; F:adenosylhomocysteinase activity; IDA:MTBBASE.
 GO:0070403; F:NAD+ binding; IDA:MTBBASE.
 GO:0046085; P:adenosine metabolic process; IDA:MTBBASE.
 GO:0040007; P:growth; IMP:MTBBASE.
 GO:0009087; P:methionine catabolic process; IDA:MTBBASE.
 GO:0006730; P:one-carbon metabolic process; IEA:HAMAP.
 GO:0051289; P:protein homotetramerization; IPI:MTBBASE. 

Interpro

 IPR000043; Adenosylhomocysteinase.
 IPR015878; Ado_hCys_hydrolase_NAD-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR020082; S-Ado-L-homoCys_hydrolase_CS. 

Pfam

 PF05221; AdoHcyase
 PF00670; AdoHcyase_NAD 

SMART

 SM00996; AdoHcyase
 SM00997; AdoHcyase_NAD 

PROSITE

 PS00738; ADOHCYASE_1
 PS00739; ADOHCYASE_2 

PRINTS