UniProt Accession

 F6ZSB7_MOUSE; F6ZSB7 

Genbank Protein ID

 AC147476 

Genbank Nucleotide ID

  

Protein Name

 D-3-phosphoglycerate dehydrogenase 

Protein Synonyms/Alias

  

Gene Name

 Phgdh 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
30	LIVRSATKVTADVIN	acetylation	[1]
30	LIVRSATKVTADVIN	ubiquitination	[2]
41	DVINAAEKLQVVGRA	acetylation	[3]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0004617; F:phosphoglycerate dehydrogenase activity; TAS:MGI.
 GO:0070314; P:G1 to G0 transition; IMP:MGI.
 GO:0009448; P:gamma-aminobutyric acid metabolic process; IMP:MGI.
 GO:0021782; P:glial cell development; IMP:MGI.
 GO:0006541; P:glutamine metabolic process; IMP:MGI.
 GO:0006544; P:glycine metabolic process; IMP:MGI.
 GO:0006564; P:L-serine biosynthetic process; IEA:InterPro.
 GO:0006563; P:L-serine metabolic process; IMP:MGI.
 GO:0021915; P:neural tube development; IMP:MGI.
 GO:0031175; P:neuron projection development; IMP:MGI.
 GO:0010468; P:regulation of gene expression; IMP:MGI.
 GO:0021510; P:spinal cord development; IMP:MGI.
 GO:0019530; P:taurine metabolic process; IMP:MGI.
 GO:0006566; P:threonine metabolic process; IMP:MGI. 

Interpro

 IPR006236; D-3-Phosphoglycerate_DH.
 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 

SMART

  

PROSITE

 PS00065; D_2_HYDROXYACID_DH_1 

PRINTS