| Tag | Content |
|---|
| CPLM ID | CPLM-005863 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-chimaerin |
Protein Synonyms/Alias | A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2 |
Gene Name | Chn1 |
Gene Synonyms/Alias | Arhgap2; Chn |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 84 | YEKVHNFKVHTFRGP | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. |
Sequence Annotation | DOMAIN 143 334 Rho-GAP.
ZN_FING 80 130 Phorbol-ester/DAG-type.
MOD_RES 215 215 Phosphothreonine. |
Keyword | Complete proteome; GTPase activation; Metal-binding; Neurogenesis; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 334 AA |
Protein Sequence | MPSKESWSGR KTNRATVHKS KQEGRQQDLL IAALGMKLGS QKSSVTIWQP LKLFAYSQLT 60
SLVRRATLKE NEQIPKYEKV HNFKVHTFRG PHWCEYCANF MWGLIAQGVK CADCGLNVHK 120
QCSKMVPNDC KPDLKHVKKV YSCDLTTLVK AHITKRPMVV DMCIREIESR GLNSEGLYRV 180
SGFSDLIEDV KMAFDRDGEK ADISVNMYED INIITGALKL YFRDLPIPLI TYDAYPKFIE 240
SAKIVDPDEQ LETLHEALRS LPPAHCETLR YLMAHLKRVT LHEKENLMSA ENLGIVFGPT 300
LMRSPELDPM AALNDIRYQR LVVELLIKNE DILF 334 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0005096; F:GTPase activator activity; TAS:RGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0001565; F:phorbol ester receptor activity; TAS:RGD. GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0008045; P:motor neuron axon guidance; ISS:UniProtKB. GO:0050770; P:regulation of axonogenesis; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |