CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015096
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Armadillo repeat-containing protein 6 
Protein Synonyms/Alias
  
Gene Name
 ARMC6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
74VDLSNIVKTAPKVSAubiquitination[1]
122TRFCDQCKQDKACRFubiquitination[2]
125CDQCKQDKACRFLAAubiquitination[2]
134CRFLAAQKGAYPIIFubiquitination[2, 3, 4, 5, 6, 7]
208CVRHACLKHEQNRQDubiquitination[1, 2, 5]
218QNRQDLVKAGVLPLLubiquitination[2]
267GHAHNHAKMIVQENKubiquitination[2]
274KMIVQENKGLKVLIEubiquitination[1, 2, 5, 6]
277VQENKGLKVLIEATKubiquitination[2]
284KVLIEATKAFLDNPGubiquitination[2, 5]
345SGVQELVKQVLSTLRubiquitination[1, 2]
361IAGNDDVKDAIVRAGubiquitination[1, 2, 5, 6]
422VAALQAMKAHPQKAGubiquitination[1, 2, 4, 7]
432PQKAGVQKQACMLIRubiquitination[2, 6]
450AHGQAFSKPILDLGAubiquitination[1, 2]
476RDCEDVAKAALRDLGubiquitination[2, 5, 6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 REPEAT 220 264 ARM 1.
 REPEAT 274 318 ARM 2.
 REPEAT 319 369 ARM 3.
 REPEAT 370 412 ARM 4.
 MOD_RES 64 64 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 501 AA 
Protein Sequence
MSERCCSRYS SGASIGCTPT STQAKMVSKR IAQETFDAAV RENIEEFAMG PEEAVKEAVE 60
QFESQGVDLS NIVKTAPKVS ADGSQEPTHD ILQMLSDLQE SVASSRPQEV SAYLTRFCDQ 120
CKQDKACRFL AAQKGAYPII FTAWKLATAG DQGLLLQSLN ALSVLTDGQP DLLDAQGLQL 180
LVATLTQNAD EADLTCSGIR CVRHACLKHE QNRQDLVKAG VLPLLTGAIT HHGHHTDVVR 240
EACWALRVMT FDDDIRVPFG HAHNHAKMIV QENKGLKVLI EATKAFLDNP GILSELCGTL 300
SRLAIRNEFC QEVVDLGGLS ILVSLLADCN DHQMRDQSGV QELVKQVLST LRAIAGNDDV 360
KDAIVRAGGT ESIVAAMTQH LTSPQVCEQS CAALCFLALR KPDNSRIIVE GGGAVAALQA 420
MKAHPQKAGV QKQACMLIRN LVAHGQAFSK PILDLGAEAL IMQARSAHRD CEDVAKAALR 480
DLGCHVELRE LWTGQRGNLA P 501 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo. 
Pfam
 PF00514; Arm 
SMART
 SM00185; ARM 
PROSITE
 PS50176; ARM_REPEAT 
PRINTS