CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025501
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 Hmgcs1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
46YDGVDAGKYTIGLGQubiquitination[1]
206QHAYDFYKPDMLSEYubiquitination[1]
273PYCKLVQKSLARMFLubiquitination[1]
291LNDQNRDKNSIYSGLubiquitination[1]
317YFDRDVEKAFMKASSubiquitination[1]
321DVEKAFMKASSELFNubiquitination[1]
330SSELFNQKTKASLLVubiquitination[1]
400TPGSALDKITASLCDubiquitination[1]
409TASLCDLKSRLDSRTubiquitination[1]
428DVFAENMKLREDTHHubiquitination[1]
498EHIPSPAKKVPRLPAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MPGSLPLNAE ACWPKDVGIV ALEIYFPSQY VDQAELEKYD GVDAGKYTIG LGQARMGFCT 60
DREDINSLCL TVVQKLMERH SLSYDCIGRL EVGTETIIDK SKSVKSKLMQ LFEESGNTDI 120
EGIDTTNACY GGTAAVFNAV NWVESSSWDG RYALVVAGDI AIYATGNARP TGGVGAVALL 180
IGPNAPLIFD RGLRGTHMQH AYDFYKPDML SEYPVVDGKL SIQCYLSALD RCYSVYRKKI 240
RAQWQKEGKD KDFTLNDFGF MIFHSPYCKL VQKSLARMFL NDFLNDQNRD KNSIYSGLEA 300
FGDVKLEDTY FDRDVEKAFM KASSELFNQK TKASLLVSNQ NGNMYTSSVY GSLASVLAQY 360
SPQQLAGKRV GVFSYGSGLA ATLYSLKVTQ DATPGSALDK ITASLCDLKS RLDSRTCVAP 420
DVFAENMKLR EDTHHLANYI PQCSIDSLFE GTWYLVRVDE KHRRTYARRP FTNDHSLDEG 480
MGLVHSNTAT EHIPSPAKKV PRLPATSAES ESAVISNGEH 520 
Gene Ontology
 GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. 
Interpro
 IPR000590; HMG_CoA_synt_AS.
 IPR013746; HMG_CoA_synt_C.
 IPR013528; HMG_CoA_synth_N.
 IPR010122; HMG_CoA_synthase_euk.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr. 
Pfam
 PF08540; HMG_CoA_synt_C
 PF01154; HMG_CoA_synt_N 
SMART
  
PROSITE
 PS01226; HMG_COA_SYNTHASE 
PRINTS