UniProt Accession

 TMED5_HUMAN; Q9Y3A6; B1AKT4; B2R703; D3DT38; Q96AX8 

Genbank Protein ID

 AF151858; AY359039; BX379269; AK312787; AL117354; AC126124; AL117354; AC126124; CH471097; CH471097; BC016365; BC016556; BC070051 

Genbank Nucleotide ID

 AAD34095.1; AAQ89398.1; BAG35650.1; CAI23500.1; CAI23500.1; CAI23501.1; CAI23501.1; EAW73081.1; EAW73082.1; AAH16365.1; AAH16556.1; AAH70051.1 

Protein Name

 Transmembrane emp24 domain-containing protein 5 

Protein Synonyms/Alias

 p24 family protein gamma-2; p24gamma2; p28 

Gene Name

 TMED5 

Gene Synonyms/Alias

 CGI-100; UNQ397/PRO733 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
164	LESINSIKSRLSKSG	ubiquitination	[1, 2]
169	SIKSRLSKSGHIQTL	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle- mediated retrograde transport. 

Sequence Annotation

 DOMAIN 45 126 GOLD.  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Membrane; Polymorphism; Protein transport; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0005801; C:cis-Golgi network; IDA:UniProtKB.
 GO:0070971; C:endoplasmic reticulum exit site; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0090161; P:Golgi ribbon formation; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR009038; GOLD. 

Pfam

 PF01105; EMP24_GP25L 

SMART

  

PROSITE

 PS50866; GOLD 

PRINTS