UniProt Accession

 CTF8_HUMAN; P0CG13; A8MYX8; Q71E72; Q8NDH8; Q8WV66; Q9NX73 

Genbank Protein ID

 AF525164; AK000407; AC009027; CH471092; BC018700 

Genbank Nucleotide ID

 AAQ08897.1; BAA91144.1; EAW83250.1; AAH18700.4 

Protein Name

 Chromosome transmission fidelity protein 8 homolog 

Protein Synonyms/Alias

 hCTF8 

Gene Name

 CHTF8 

Gene Synonyms/Alias

 CTF8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
68	GKIIHLEKPFAVLVK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression. 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell cycle; Complete proteome; DNA replication; DNA-binding; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 121 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 

Interpro

 IPR018607; Chromosome_trans_fidel_Ctf8. 

Pfam

 PF09696; Ctf8 

SMART

  

PROSITE

  

PRINTS