CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040589
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho guanine nucleotide exchange factor 12 
Protein Synonyms/Alias
  
Gene Name
 Arhgef12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
808RAHVRTLKVLDQVFYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1544 AA 
Protein Sequence
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERSS SHDFDPTDSS SKKTKSSSEE 60
SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED GAAMRAGVQT GDRIIKVNGT 120
LVTHSNHLEV VKLIRSGSYV ALTVQGRPPG SPQIPLADSE VEPSVTGHMS PIMTSPHSPG 180
AAGNMERITS PVLVGEENNV VHNQKVEILR KMLQKEQERL QLLQEDYNRT ATQRLLKEIQ 240
EAKKHIPQLQ EQLSKATGSA QDGAVIAPSR PLGDALTLSE AEADPGDGLC RTDWSSGDAS 300
RPSSDSADSP KSSLRERSYL EEAPERSEGV QDAQEPQSLV GSPSTRGAPH IIGAEDDDFG 360
TEHEQINGQC SCFQSIELLK SRPAHLAVFL HHVVSQFDPA TLLCYLYSDL YKQTNSKETR 420
RVFLEFHQFF LDRSAHLKVP VPEEISVDLE KRRPELIPED LHRLYIQTMQ ERVHPEVQRH 480
LEDFRQKRSM GLTLAESELT KLDAERDKDR GTLEKERACA EQIVTKIEEV LMTAQAVEEE 540
RSSTMQYVIL MYMKYLGVKV KEPRNLEHKR GRIGFLPKIK QSMKKDREGE EKGKRRGFPS 600
ILGPPRRPSR HDNSAIGRAM EIQKSRHPKH LSTPSSVSPE PQDPAKLRQS GVANEGTDTG 660
YLPASSMSSA TSGTALSQEG GRENDTGTKQ VGEASAPGDC LDSTPRVPTT VFDFPPPLLD 720
QVQEEECEVE RVAEHGTPKP FRKFDSIAFG ESQSEDEQFE NDLETDPPNW QQLVSREVLL 780
GLKPSEIKRQ EVINELFYTE RAHVRTLKVL DQVFYQRVSR EGILSPSELR KIFSNLEDIL 840
QLHVGLNEQM KAVRKRNETS VIDHIGEDLL IWFSGPGEEK LKHAAATFCS NQPFALEMIK 900
SRQKKDSRFH TFVQDAESNP LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK YTEWPPEREK 960
VKKAADHCRQ ILNYVNQAVR EAENKQRLED YQRRLDTSNL KLSEYPNVDE LRNLDLTKRK 1020
MIHEGPLVWK VNRDKSIDLY TLLLEDILVL LQKQDDRLVL RCHSKILAST ADSKHTFSPV 1080
IKLSTVLVRQ VATDNKALFV ISMSDNGAQI YELVAQTVSE KTVWQDLICR MAASVKEQST 1140
KPIPLPQPPP CEGDNDEEEP AKLKVEHHDL SVAGLQSPDR VLGLESPLIS SKPQSHSLNT 1200
PGKSAAEHLF VTATQFAKEQ HANGALKEGD GGYPVTIPGP HLPVSEERWA LDALRNLGLL 1260
KQLLVQQLGL TEKSTQEDWQ SFSRYGPASE EVQADSGIRD LENVKACHAR EGQMSFKTGT 1320
GDIATCDSPR TSTESCAAQD SVILASQDSQ ASNVLVMDHM ILTPEMPPAE PEGGLDESGE 1380
HFFDAREAHS DDNPSEGDGA VKKEEKDVNL RISGNCLILD GYDAVQESST DEEVASSFPL 1440
QPVTGIPAVD SSHQQQHSPQ NVHPEGPVSP FTPEFLVQRH WRAMEDTCFE IQSPSCTDSQ 1500
SQILEYIHKI EADLEHLKKV EESYALLCQR LAGSALPDKL SDKS 1544 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR001478; PDZ.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR015212; Regulat_G_prot_signal-like.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR015721; RhoGEF-like. 
Pfam
 PF00595; PDZ
 PF09128; RGS-like
 PF00621; RhoGEF 
SMART
 SM00228; PDZ
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS50106; PDZ
 PS50003; PH_DOMAIN 
PRINTS