UniProt Accession

 IFM2_MOUSE; Q99J93; Q3TIG4 

Genbank Protein ID

 AY082486; AK141392; AK167865; CH466531; BC002102; BC002160; BC084679 

Genbank Nucleotide ID

 AAM03318.1; BAE24670.1; BAE39882.1; EDL17975.1; AAH02102.1; AAH02160.1; AAH84679.1 

Protein Name

 Interferon-induced transmembrane protein 2 

Protein Synonyms/Alias

 Dispanin subfamily A member 2c; DSPA2c; Fragilis protein 3 

Gene Name

 Ifitm2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
23	PPSYETIKEEYGVTE	ubiquitination	[1]
87	SVKSRDRKMVGDVVG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53- independent manner. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 LIPID 70 70 S-palmitoyl cysteine (By similarity).
 LIPID 71 71 S-palmitoyl cysteine (By similarity).
 LIPID 104 104 S-palmitoyl cysteine (By similarity).  

Keyword

 Acetylation; Antiviral defense; Cell membrane; Complete proteome; Immunity; Innate immunity; Lipoprotein; Membrane; Palmitate; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 144 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0051607; P:defense response to virus; IDA:MGI.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB. 

Interpro

 IPR007593; Interferon-induced_TM_protein. 

Pfam

 PF04505; CD225 

SMART

  

PROSITE

  

PRINTS