CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037604
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Bcl-2-associated transcription factor 1 
Protein Synonyms/Alias
  
Gene Name
 BCLAF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
330GGDQETAKTGKFLKSacetylation[1, 2]
330GGDQETAKTGKFLKSubiquitination[3, 4]
333QETAKTGKFLKSPPLacetylation[1, 5]
392NRPASLTKDRLLASTubiquitination[6]
418RSIFDHIKLPQASKSubiquitination[6]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 467 AA 
Protein Sequence
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYRSRSRT YSRSRSRDRM YSRDYRRDYR 60
NNRGMRRPYG YRGRGRGYYQ GGGGRYHRGG YRPVWNRRHS RSPRRGRSRS RSPKRRSVSS 120
QRSRSRSRRS YRSSRSPRSS SSRSSSPYSK SPVSKRRGSQ EKQTKKAEGE PQEESPLKSK 180
SQEEPKDTFE HDPSESIDEF NKSSATSGDI WPGLSAYDNS PRSPHSPSPI ATPPSQSSSC 240
SDAPMLSTVH SAKNTPSQHS HSIQHSPERS GSGSVGNGSS RYSPSQNSPI HHIPSRRSPA 300
KTIAPQNAPR DESRGRSSFY PDGGDQETAK TGKFLKSPPL HKNLDAREKS TFREESPLRI 360
KMIASDSHRP EVKLKMAPVP LDDSNRPASL TKDRLLASTL VHSVKKEQEF RSIFDHIKLP 420
QASKSTSESF IQHIVSLVHH VKGPGICFEM AKSMFQSKIA VERYRQS 467 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0006917; P:induction of apoptosis; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:InterPro.
 GO:2001022; P:positive regulation of response to DNA damage stimulus; IEA:InterPro. 
Interpro
 IPR026668; Bcl-2_assoc_TF1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS