CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000973
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Perilipin-3 
Protein Synonyms/Alias
 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; Mannose-6-phosphate receptor-binding protein 1; Placental protein 17; PP17 
Gene Name
 PLIN3 
Gene Synonyms/Alias
 M6PRBP1; TIP47 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65TVCDAAEKGVRTLTAacetylation[1]
65TVCDAAEKGVRTLTAubiquitination[2]
84GAQPILSKLEPQIASubiquitination[3]
116ILQQPTEKVLADTKEubiquitination[3]
122EKVLADTKELVSSKVubiquitination[3, 4]
128TKELVSSKVSGAQEMubiquitination[3]
140QEMVSSAKDTVATQLubiquitination[3]
195GVDTVLGKSEEWADNubiquitination[3]
307MWLSWNQKQLQGPEKubiquitination[5]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 65 65 N6-acetyllysine.
 MOD_RES 130 130 Phosphoserine.
 MOD_RES 170 170 Phosphothreonine.
 MOD_RES 175 175 Phosphoserine.
 MOD_RES 179 179 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Endosome; Lipid droplet; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 434 AA 
Protein Sequence
MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHIKTVC 60
DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD 120
TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR 180
LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG 240
SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM 300
WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG LPTNVKDQVQ 360
QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA LDHMVEYVAQ NTPVTWLVGP 420
FAPGITEKAP EEKK 434 
Gene Ontology
 GO:0005768; C:endosome; TAS:ProtInc.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; TAS:ProtInc.
 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0016192; P:vesicle-mediated transport; TAS:ProtInc. 
Interpro
 IPR004279; Perilipin. 
Pfam
 PF03036; Perilipin 
SMART
  
PROSITE
  
PRINTS