| Tag | Content |
|---|
| CPLM ID | CPLM-001041 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma |
Protein Synonyms/Alias | PI3K-C2-gamma; PtdIns-3-kinase C2 subunit gamma; Phosphoinositide 3-kinase-C2-gamma |
Gene Name | Pik3c2g |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 357 | GSHKIFQKNKSVIQL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis. |
Sequence Annotation | DOMAIN 285 371 PI3K-RBD.
DOMAIN 541 689 C2 PI3K-type.
DOMAIN 704 880 PIK helical.
DOMAIN 977 1241 PI3K/PI4K.
DOMAIN 1260 1372 PX.
DOMAIN 1403 1500 C2. |
Keyword | Alternative splicing; ATP-binding; Chemotaxis; Complete proteome; Kinase; Membrane; Nucleotide-binding; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1506 AA |
Protein Sequence | MAYSWQTEPN RTEPQEDGSD TQQFHHTNQH LSSRQVRLGF DQLVEEINNK TPLSESEKEE 60
DTYFVPDAPN LGSKWPSIYE THPRYFSEFT SQSPDSSQLR FGKLSAIGFN PAVLPTHQLI 120
HEGASWRNPS GKYHGIEYPR FDALPPSSTG QGECNPQGQS GTKHHNYCGE HEGNLPHHHS 180
SYSIDSIPNR EKRRSGDVNL VEPSLEFSKD SFLPRTSENV SVESTEPIGC PIEIVEVPQG 240
SNKNLASFCN KVKKIRESYH ASDINSNSGK IWAITTAYPS RLFADTKFRV KISIDNSAQL 300
LLLMPHANYL VKDLIAEILL LCANEPLSPK EYLLSVCGSE EFLQMDHSLG SHKIFQKNKS 360
VIQLHLQKNR DTPGKLSRKS EDDHSPFHLN QLLEFTHIWK ISRQCLSTVM KKYNLHVEHL 420
LKPQKDMEEK HLSSMVSGNQ HTSQPHVNNV LEEVKNICSV LGCIETKQVS DAVKELNLIL 480
QRPSQNFHQN SETSKKGFIE RVTAELSRSI YQLIDVYCSS FCTDFQPVHT PGGVSHVHAG 540
LQSHLSFTVC SLHNVPETWA HSYKAFSFSC WLTYAGKKLC QVKSCRPLPV TKSFSLLVNW 600
NEIINFPLEI KSLPRESMLV IKLFGIDSAT HSTNLLAWTC LPLFPRQESV LGSRLFSVTL 660
QSEPPIEMIA PGVWDGSQPS PLTLQIDFPD AGWEYLKPES EENRTDHEEP PRECLKHIAK 720
LSQKKSPLLL SEEKRRYLWF YRLYCNNENS SLPLVLGSAP GWDEETVSEM HAILRRWTFS 780
HPWEALGLLT SRFPDQDIRE VAVQQLDTLL TDELLDCLPQ LVQAVKFEWN LESPLVELLP 840
RRPLQSIRVA HCLYWLLRDA QGEAYFKSWY QELLAALQFC AGEALNEELS KEQKLVKLLG 900
DIGEKVKSAS DPQRKDVLKK EIGSLEEFFK DIKTCHLPLN PALCIKGIDR DACSYFTSNA 960
SPLKITFINA NPMGKNISVI FKAGDDLRQD MLALQIIQVM DNAWLQEGLD MQMITYGCLS 1020
TGRAQGFIEM VPDAVTLAKI HLHSGLIGPL KENTIKKWFS QHNHLKEDYE KALRNFFYSC 1080
AGWCVVTFIL GVCDRHNDNI MLTKSGHMFH IDFGKFLGHA QTFGGIKRDR APFIFTSEME 1140
YFITEGGKNI QHFQDFVELC CRAYNIVRKH SQLILSLLEM MLHAGLPELR GIEDLKYVHN 1200
NLRPQDTDLE ATSHFTKKIK ESLECFPVKL NNLIHTLAQM PALSLAKPAP QTLLQESCIL 1260
NKTRTIQRVT ILGFSKTHSN LYLMEVTCSD NRRSLTKKSF EQFYRLHSQM QKQFSSLALP 1320
EFPHWWHLPF TDSDHKRIRD LSHYVEQVLR GSYEVANSDC VLSFFLSEHI QPTLEDSPFV 1380
DPGENSLDKS PKVQLLMTYE DSRLTILVKH LKNIHLPDGS VPSAHVEIYL LPHPSEVRRK 1440
KTKCVPKCTD PTYNEIVVYD EVLGLQGHVL MLIVKSKTVF VGAVNIQLCS VPLNEEKWYP 1500
LGNSII 1506 |
Gene Ontology | GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:RefGenome. GO:0005886; C:plasma membrane; IBA:RefGenome. GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IBA:RefGenome. GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IBA:RefGenome. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0035091; F:phosphatidylinositol binding; IEA:InterPro. GO:0006935; P:chemotaxis; IMP:UniProtKB. GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |