| Tag | Content |
|---|
| CPLM ID | CPLM-013112 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tax1-binding protein 1 homolog |
Protein Synonyms/Alias | |
Gene Name | Tax1bp1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 173 | KLIAVLEKETAQLRE | ubiquitination | [1] | | 244 | DIVSVTHKAIEKETD | ubiquitination | [1] | | 288 | ELYKVHLKNTEIENT | ubiquitination | [1] | | 305 | VSEIQTLKNLDGNKE | ubiquitination | [1] | | 563 | KYAEELAKMELKWKE | ubiquitination | [1] | | 598 | VQLAEKEKEINGLAS | ubiquitination | [1] | | 618 | SREKELTKSLEDQKG | ubiquitination | [1] | | 627 | LEDQKGRKLEGQSPQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). |
Sequence Annotation | REGION 320 420 Oligomerization (By similarity).
MOD_RES 225 225 Phosphoserine (By similarity).
MOD_RES 619 619 Phosphoserine; by IKKA (Probable).
MOD_RES 693 693 Phosphoserine; by IKKA (Probable). |
Keyword | Apoptosis; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 814 AA |
Protein Sequence | MTSFQEVQLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHSKDWV GIFKVGWSTA 60
RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 120
RAASPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTLKE KEELLKLIAV LEKETAQLRE 180
QVGRMERELS QEKGRCEQLQ AEQKGLLEVS QSLRVENEEF MKRYSDATAK VQQLEEDIVS 240
VTHKAIEKET DLDSLKDKLR KAQHEREQLE CQLQTEKDEK ELYKVHLKNT EIENTKLVSE 300
IQTLKNLDGN KESMITHFKE EISKLQSCLA DKENLYRALL LTTSNKEDTL FLKEQLRKAE 360
EQVQATRQEL IFLTKELSDA VNVRDKTMAD LHTARLENER VKKQLADTLA ELQLHAVKKD 420
QEKTDTLEHE LRREVEDLKL RLQMAADHYR EKFKECQRLQ KQINKLSDQA ASTNSVFTKK 480
MGSQQKVNDA SINTDPAAST SASAVDVKPA ASCAETGFDM STKDHVCEMT KEIAEKIEKY 540
NKCKQLLQDE KTKCNKYAEE LAKMELKWKE QVKIAENVKL ELAEVEDNYK VQLAEKEKEI 600
NGLASYLENL SREKELTKSL EDQKGRKLEG QSPQQVSRCL NTCSEQNGLL PPLSSAQPVL 660
QYGNPYSAQE TRDGADGAFY PDEIQRPPVR VPSWEDNVVC SQPARNLSRP DGLEDPEDSR 720
EDENVPIPPD PANQHLRSHG AGFCFDSSFD VHKKCPLCEL MFPPNYDQTK FEEHVESHWK 780
VCPMCSEQFP PDYDQQGFER HVQTHFDQNV LNFD 814 |
Gene Ontology | GO:0043130; F:ubiquitin binding; NAS:BHF-UCL. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0043066; P:negative regulation of apoptotic process; IEA:Compara. GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |