UniProt Accession

 B2R532_HUMAN; B2R532 

Genbank Protein ID

 BC143701; AK312042; CH471065 

Genbank Nucleotide ID

 AAI43702.1; BAG34979.1; EAW67250.1 

Protein Name

 REX2, RNA exonuclease 2 homolog (S. cerevisiae) 

Protein Synonyms/Alias

 REX2, RNA exonuclease 2 homolog (S. cerevisiae), isoform CRA_b; cDNA, FLJ92319, highly similar to Homo sapiens REX2, RNA exonuclease 2 homolog (S. cerevisiae) (REXO2), mRNA 

Gene Name

 REXO2 

Gene Synonyms/Alias

 hCG_38016 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
160	KYMPQFMKHLHYRII	ubiquitination	[1]
173	IIDVSTVKELCRRWY	ubiquitination	[1, 2]
205	DDISESIKELQFYRN	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 Exonuclease; Hydrolase; Nuclease. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 

Interpro

 IPR006055; Exonuclease.
 IPR013520; Exonuclease_RNaseT/DNA_pol3.
 IPR022894; Oligoribonuclease.
 IPR012337; RNaseH-like_dom. 

Pfam

 PF00929; RNase_T 

SMART

 SM00479; EXOIII 

PROSITE

  

PRINTS