UniProt Accession

 I7HJJ0_HUMAN; I7HJJ0 

Genbank Protein ID

 AL683870 

Genbank Nucleotide ID

  

Protein Name

 ADP/ATP translocase 3 

Protein Synonyms/Alias

  

Gene Name

 SLC25A6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	EQAISFAKDFLAGGI	ubiquitination	[1]
23	GIAAAISKTAVAPIE	acetylation	[2, 3]
23	GIAAAISKTAVAPIE	ubiquitination	[1]
33	VAPIERVKLLLQVQH	acetylation	[4, 5]
33	VAPIERVKLLLQVQH	ubiquitination	[1, 6, 7]
43	LQVQHASKQIAADKQ	ubiquitination	[1, 8]
52	IAADKQYKGIVDCIV	methylation	[9]
63	DCIVRIPKEQGVLSF	ubiquitination	[1, 5, 6, 7]
92	QALNFAFKDKYKQIF	acetylation	[2, 3, 5]
92	QALNFAFKDKYKQIF	ubiquitination	[1, 7, 8]
94	LNFAFKDKYKQIFLG	ubiquitination	[7]
96	FAFKDKYKQIFLGGV	acetylation	[2, 3, 5]
96	FAFKDKYKQIFLGGV	ubiquitination	[1, 7]
105	IFLGGVDKHTQFWRY	acetylation	[2, 4, 5]
105	IFLGGVDKHTQFWRY	ubiquitination	[1, 7]
147	RLAADVGKSGTEREF	ubiquitination	[1, 5, 7, 8]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [7] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [8] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [9] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 158 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:InterPro.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 

Interpro

 IPR002113; Aden_trnslctor.
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF00153; Mito_carr 

SMART

  

PROSITE

 PS50920; SOLCAR 

PRINTS

 PR00927; ADPTRNSLCASE.
 PR00926; MITOCARRIER.