CPLM-002103

Genbank Nucleotide ID

Superoxide dismutase [Mn], mitochondrial

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
68	NLNVTEEKYQEALAK	acetylation	[1, 2, 3]
130	RDFGSFDKFKEKLTA	acetylation	[1, 2]
130	RDFGSFDKFKEKLTA	ubiquitination	[4, 5, 6]

[1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[2] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
[3] Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS.
Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S, Xiong Y.
EMBO Rep. 2011 Jun;12(6):534-41. [PMID: 21566644]
[4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

METAL 50 50 Manganese.
METAL 98 98 Manganese.
METAL 183 183 Manganese.
METAL 187 187 Manganese.
MOD_RES 58 58 Nitrated tyrosine.
MOD_RES 68 68 N6-acetyllysine.
MOD_RES 130 130 N6-acetyllysine.

3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Manganese; Metal-binding; Mitochondrion; Nitration; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
GO:0005759; C:mitochondrial matrix; TAS:BHF-UCL.
GO:0042645; C:mitochondrial nucleoid; IEA:Compara.
GO:0003677; F:DNA binding; IEA:Compara.
GO:0030145; F:manganese ion binding; IDA:UniProtKB.
GO:0019825; F:oxygen binding; IEA:Compara.
GO:0004784; F:superoxide dismutase activity; IDA:UniProtKB.
GO:0001315; P:age-dependent response to reactive oxygen species; IMP:UniProtKB.
GO:0071361; P:cellular response to ethanol; IEA:Compara.
GO:0003032; P:detection of oxygen; IEA:Compara.
GO:0048773; P:erythrophore differentiation; IEA:Compara.
GO:0006749; P:glutathione metabolic process; IEA:Compara.
GO:0007507; P:heart development; IEA:Compara.
GO:0030097; P:hemopoiesis; IEA:Compara.
GO:0050665; P:hydrogen peroxide biosynthetic process; IEA:Compara.
GO:0055072; P:iron ion homeostasis; IEA:Compara.
GO:0001889; P:liver development; IEA:Compara.
GO:0007626; P:locomotory behavior; IEA:Compara.
GO:0008285; P:negative regulation of cell proliferation; IMP:BHF-UCL.
GO:0045599; P:negative regulation of fat cell differentiation; IEA:Compara.
GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Compara.
GO:0043524; P:negative regulation of neuron apoptotic process; IGI:BHF-UCL.
GO:0048666; P:neuron development; IEA:Compara.
GO:0032364; P:oxygen homeostasis; IMP:BHF-UCL.
GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara.
GO:0009791; P:post-embryonic development; IEA:Compara.
GO:0051289; P:protein homotetramerization; IPI:UniProtKB.
GO:0050790; P:regulation of catalytic activity; IEA:Compara.
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Compara.
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO:0001836; P:release of cytochrome c from mitochondria; ISS:BHF-UCL.
GO:0019430; P:removal of superoxide radicals; IMP:BHF-UCL.
GO:0022904; P:respiratory electron transport chain; IEA:Compara.
GO:0014823; P:response to activity; IEA:Compara.
GO:0048678; P:response to axon injury; IEA:Compara.
GO:0046686; P:response to cadmium ion; IEA:Compara.
GO:0042493; P:response to drug; IEA:Compara.
GO:0051602; P:response to electrical stimulus; IEA:Compara.
GO:0010332; P:response to gamma radiation; IEA:Compara.
GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
GO:0055093; P:response to hyperoxia; IEA:Compara.
GO:0001666; P:response to hypoxia; IEA:Compara.
GO:0033591; P:response to L-ascorbic acid; IEA:Compara.
GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
GO:0010042; P:response to manganese ion; IEA:Compara.
GO:0010269; P:response to selenium ion; IEA:Compara.
GO:0034021; P:response to silicon dioxide; IEA:Compara.
GO:0010043; P:response to zinc ion; IEA:Compara.
GO:0042554; P:superoxide anion generation; IEA:Compara.
GO:0003069; P:vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure; ISS:BHF-UCL.

IPR001189; Mn/Fe_SOD.
IPR019833; Mn/Fe_SOD_BS.
IPR019832; Mn/Fe_SOD_C.
IPR019831; Mn/Fe_SOD_N.

PF02777; Sod_Fe_C
PF00081; Sod_Fe_N

PR01703; MNSODISMTASE.