CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037492
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Maestro heat-like repeat-containing protein family member 1 
Protein Synonyms/Alias
  
Gene Name
 MROH1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98LASSEMTKTKDLVWDubiquitination[1]
276GILALYKKHAETFYLubiquitination[2]
514SLVHLAQKRQEAGADubiquitination[2]
645YDEAPQEKNFLYKCIubiquitination[2]
650QEKNFLYKCIGTTLGubiquitination[2]
662TLGAASSKEVVRKHLubiquitination[2]
667SSKEVVRKHLQELLEubiquitination[2]
717VRSEVFRKSIGILNIubiquitination[2, 3]
726IGILNIFKDRSENEVubiquitination[1]
759PRELVLAKVESDILRubiquitination[1, 2]
808GSFHFTRKAELVAQMubiquitination[2]
920EHLSPWIKSPRGHERubiquitination[2]
1011AERLLSLKDGLVHPDubiquitination[2]
1082RGGVLQEKVPEIVSVubiquitination[1, 2, 4, 5]
1168MSRDVPFKESRAFLLubiquitination[1, 2]
1388LASGCPDKVRTHGPQubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1632 AA 
Protein Sequence
MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP 60
YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ 120
FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT 180
VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR 240
LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR 300
TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT 360
SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL DTNSKVKRAV VQVISAMAHH 420
GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP GPGSKDPKAD SVRAISVRTL YLVSTTVDRM 480
SHVLWPYLLQ FLTPVRFTGA LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT 540
GRLLVVSSSP YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DEHTEETLPQ 600
EEWEEKLLMF LRDTLAIISD NAWICQLSLE LCRQLPCYDE APQEKNFLYK CIGTTLGAAS 660
SKEVVRKHLQ ELLETARYQE EAEREGLACC FGICAISHLE DTLAQLEDFV RSEVFRKSIG 720
ILNIFKDRSE NEVEKVKSAL ILCYGHVAAR APRELVLAKV ESDILRNICQ HFSTKDPALK 780
LCLVQSVCMV SRAICSSTQA GSFHFTRKAE LVAQMMEFIR AEPPDSLRTP IRKKAMLTCT 840
YLVSVEPALD EQARADVIHG CLHSIMALLP EPKEEDGGCQ KSLYLETLHA LEDLLTSLLQ 900
RNMTPQGLQI MIEHLSPWIK SPRGHERARA LGLSALLLRY FLEHLRVSAL VPFHNLGLLI 960
GLFSPRCADL WPATRQEAVD CVYSLLYLQL GYEGFSRDYR DDVAERLLSL KDGLVHPDPA 1020
ILFHTCHSVG QIIAKRLPPD QLISLLLTMF EALGDPEKNC SRAATVMINC LLQERGGVLQ 1080
EKVPEIVSVL RSKLQEAQGE HVLPAAQHSV YLLATQHCAA VVSSLLGSPL PLDSHTCMLW 1140
RALAVEPRLA AQVLGLLLEK MSRDVPFKES RAFLLGRTPD RVATLLPLSA TCALFEVMST 1200
PAAGPAVLEL YPQLFVVLLL RVSCTVGVQL PRNLQAQERR GASPALATRN LEPCSSAVDT 1260
LRSMLLRSGS EDVVQRMDLE GGWELLRTSA GHEEGATRLA RAMAEHAGPR LPLVLKTLAC 1320
THSSAYENQR VTTTAFLAEL LNSNVANDLM LLDSLLESLA ARQKDTCASV RRLVLRGLAN 1380
LASGCPDKVR THGPQLLTAM IGGLDDGDNP HSPVALEAML GLARLVHLVE SWDLRSGLLH 1440
VAIRIRPFFD SEKMEFRTAS IRLFGHLNKV CHGDCEDVFL DQVVGGLAPL LLHLQDPQAT 1500
VASACRFALR MCGPNLACEE LSAAFQKHLQ EGRALHFGEF LNTTCKHLMH HFPDLLGRLL 1560
TTCLFYFKSS WENVRAAAPL FTGFLVLHSE PRQQPQVDLD QLIAALQILL KDPAPEVRTR 1620
AAEALGRLVK LA 1632 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR021133; HEAT_type_2. 
Pfam
  
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS