CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020683
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NSFL1 cofactor p47 
Protein Synonyms/Alias
 p97 cofactor p47 
Gene Name
 Nsfl1c 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
146KSPGETSKPRPFAGGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). 
Sequence Annotation
 DOMAIN 179 244 SEP.
 DOMAIN 291 368 UBX.
 MOTIF 109 115 Nuclear localization signal.
 MOTIF 172 175 Nuclear localization signal.
 MOD_RES 74 74 Phosphoserine.
 MOD_RES 114 114 Phosphoserine.
 MOD_RES 140 140 Phosphoserine.
 MOD_RES 167 167 Phosphotyrosine.
 MOD_RES 176 176 Phosphoserine.
 MOD_RES 272 272 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Chromosome; Complete proteome; Golgi apparatus; Lipid-binding; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 370 AA 
Protein Sequence
MAEERQDALR EFVAVTGTEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS 60
VSRGTAPSDN RVTSFRDLIH DQDEEEEEEE GQRFYAGGSE RSGQQIVGPP RKKSPNELVD 120
DLFKGAKEHG AVAVERVTKS PGETSKPRPF AGGGYRLGAA PEEESAYVAG ERRRHSGQDV 180
HVVLKLWKTG FSLDNGDLRS YQDPSNAQFL ESIRRGEVPA ELRRLAHGGQ VNLDMEDHRD 240
EDFVKPKGAF KAFTGEGQKL GSTAPQVLNT SSPAQQAENE AKASSSILIN EAEPTTNIQI 300
RLADGGRLVQ KFNHSHRISD IRLFIVDARP AMAATSFVLM TTFPNKELAD ENQTLKEANL 360
LNAVIVQRLT 370 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW. 
Interpro
 IPR012989; SEP_domain.
 IPR009060; UBA-like.
 IPR001012; UBX. 
Pfam
 PF08059; SEP
 PF00789; UBX 
SMART
 SM00553; SEP
 SM00166; UBX 
PROSITE
 PS51399; SEP
 PS50033; UBX 
PRINTS