UniProt Accession

 ESTD_MOUSE; Q9R0P3; Q80ZX4; Q9CWI4 

Genbank Protein ID

 AB025408; AK007527; AK010683; AK021209; AK079131; AK088115; BC046766 

Genbank Nucleotide ID

 BAA84693.1; BAB25090.1; BAB27115.1; BAB32330.1; BAC37555.1; BAC40154.1; AAH46766.2 

Protein Name

 S-formylglutathione hydrolase 

Protein Synonyms/Alias

 FGH; Esterase 10; Esterase D; Sid 478 

Gene Name

 Esd 

Gene Synonyms/Alias

 Es10; Sid478 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
4	****MALKQISSNRC	ubiquitination	[1]
17	RCFGGLQKVFEHSSV	ubiquitination	[1]
27	EHSSVELKCKMRFAV	ubiquitination	[1]
185	PVLCSWGKKAFSGYL	ubiquitination	[1]
186	VLCSWGKKAFSGYLG	ubiquitination	[1]
198	YLGPDESKWKAYDAT	acetylation	[2]
198	YLGPDESKWKAYDAT	ubiquitination	[1]
200	GPDESKWKAYDATCL	ubiquitination	[1]
247	IAACTEKKIPVVFRL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Serine hydrolase involved in the detoxification of formaldehyde (By similarity). 

Sequence Annotation

 ACT_SITE 149 149 Charge relay system (By similarity).
 ACT_SITE 226 226 Charge relay system (By similarity).
 ACT_SITE 260 260 Charge relay system (By similarity).
 MOD_RES 200 200 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Hydrolase; Reference proteome; Serine esterase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 282 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0016788; F:hydrolase activity, acting on ester bonds; IDA:MGI.
 GO:0018738; F:S-formylglutathione hydrolase activity; IEA:EC.
 GO:0046294; P:formaldehyde catabolic process; IEA:InterPro. 

Interpro

 IPR000801; Esterase_put.
 IPR014186; S-formylglutathione_hydrol. 

Pfam

 PF00756; Esterase 

SMART

  

PROSITE

  

PRINTS