| Tag | Content |
|---|
| CPLM ID | CPLM-014161 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aldehyde dehydrogenase family 3 member B1 |
Protein Synonyms/Alias | |
Gene Name | Aldh3b1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 148 | EISKATEKILAEVLP | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Oxidizes medium and long chain saturated and unsaturated aldehydes (By similarity). Metabolizes also benzaldehyde (By similarity). Low activity towards acetaldehyde and 3,4- dihydroxyphenylacetaldehyde (By similarity). May not metabolize short chain aldehydes (By similarity). May use both NADP(+) and NAD(+) as cofactors (By similarity). May have a protective role against the cytotoxicity induced by lipid peroxidation (By similarity). |
Sequence Annotation | NP_BIND 188 193 NAD (By similarity).
ACT_SITE 210 210 By similarity.
ACT_SITE 244 244 By similarity. |
Keyword | Complete proteome; NAD; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 468 AA |
Protein Sequence | MDSFEDKLQQ LREAFNAGRT RSAEFRAAQL QGLSHFLRDN KQQLQEALAQ DLHKSAFESE 60
VSEIAISQAE VDLALRNLRS WMKDEKVSKN LATQLDSAFI RKEPFGLVLI IVPWNYPLNL 120
TLVPLVGAIA AGNCVVLKPS EISKATEKIL AEVLPRYLDQ SCFAVVLGGP QETGQLLEHR 180
FDYIFFTGNT YVGKIVMAAA AKHLTPITLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA 240
GQTCVAPDYV LCSQEMQERL VPALQNAITR FYGDNPQTSP NLGRIINQKH FERLQGLLGC 300
GRVAIGGQSD EGERYIAPTV LVDVQETEPV MQEEIFGPIL PLVTVTNLDE AIEFINRREK 360
PLALYAFSKR SQVIKQVLAR TSSGGFCGND GFMHMTLSSL PFGGVGTSGM GRYHGKFSFD 420
TFSNQRACLL RSPGMEKIND LRYPPYTSRN LRVLLVAMEK RCCSCTLL 468 |
Gene Ontology | GO:0005829; C:cytosol; IEA:Compara. GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:EC. GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro. GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |