CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004720
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Stress protein DDR48 
Protein Synonyms/Alias
 DNA damage-responsive protein 48; DDRP 48; Flocculent-specific protein; YP 75 
Gene Name
 DDR48 
Gene Synonyms/Alias
 FSP; YMR173W; YM8010.03 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
8MGLFDKVKQFANSNNubiquitination[1]
55IGEDRFDKMESKVRQacetylation[2]
178YGSSNKNKSSYGSNNubiquitination[1]
202DSYGSSNKKKSSYGSubiquitination[3]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Dispensable for acquisition of thermotolerance and does not play a significant role in recovery or protection of cells from acute heat shock. May be implicated in one or possibly more pathways of mutagenesis in yeast. Hydrolyzes ATP and GTP yielding ppi. 
Sequence Annotation
 REPEAT 74 81 1.
 REPEAT 82 89 2.
 REPEAT 90 97 3.
 REPEAT 98 105 4.
 REPEAT 106 113 5.
 REPEAT 114 121 6.
 REPEAT 124 131 7; approximate.
 REPEAT 132 139 8.
 REPEAT 141 148 9.
 REPEAT 149 156 10.
 REPEAT 157 164 11.
 REPEAT 165 172 12.
 REPEAT 175 182 13; approximate.
 REPEAT 183 190 14.
 REPEAT 191 198 15.
 REPEAT 201 208 16; approximate.
 REPEAT 209 216 17.
 REPEAT 217 224 18.
 REPEAT 225 232 19.
 REPEAT 233 240 20.
 REPEAT 243 250 21; approximate.
 REPEAT 251 258 22.
 REPEAT 260 267 23.
 REPEAT 268 275 24.
 REPEAT 278 285 25; approximate.
 REPEAT 287 294 26.
 REPEAT 296 303 27.
 REPEAT 306 313 28; approximate.
 REPEAT 314 321 29.
 REPEAT 322 329 30.
 REPEAT 332 339 31; approximate.
 REPEAT 340 347 32.
 REPEAT 348 355 33.
 REPEAT 358 365 34; approximate.
 REPEAT 366 373 35.
 REPEAT 375 382 36.
 REPEAT 393 400 37; approximate.
 REPEAT 407 414 38.
 REGION 74 414 38 X 8 AA approximate tandem repeats of
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 191 191 Phosphoserine.
 MOD_RES 314 314 Phosphoserine.
 MOD_RES 322 322 Phosphoserine.  
Keyword
 Complete proteome; Direct protein sequencing; Glycoprotein; Phosphoprotein; Reference proteome; Repeat; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 430 AA 
Protein Sequence
MGLFDKVKQF ANSNNNNNDS GNNNQGDYVT KAENMIGEDR VNQFKSKIGE DRFDKMESKV 60
RQQFSNTSIN DNDSNNNDSY GSNNNDSYGS NNNDSYGSNN NDSYGSNNND SYGSNNDDSY 120
GSSNKKKSSY GSNNDDSYGS SNNNDSYGSN NNDSYGSNNN DSYGSNNDDS YGSSNKNKSS 180
YGSNNDDSYG SNNDDSYGSS NKKKSSYGSS NNDSYGSNND DSYGSNNNDS YGSNNDDSYG 240
SSNKKKSSYG SNNDDSYGSS NNNDSYGSNN DDSYGSSNKN KSSYGSSSND DSYGSSNNDD 300
SYGSSNKKKS SYGSNNDDSY GSNNDDSYGS SNKKKSSYGS SNNDSYGSNN DDSYGSSNKK 360
KSSYGSNNDD SYGSSNNNDS YGSNNDDSYG SSNRNKNSYG SSNYGSSNND DSYGSSNRGG 420
RNQYGGDDDY 430 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0016887; F:ATPase activity; IDA:SGD.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0006281; P:DNA repair; IMP:SGD. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS