UniProt Accession

 IRK2_MOUSE; P35561 

Genbank Protein ID

 X73052; AF021136 

Genbank Nucleotide ID

 CAA51526.1; AAB88794.1 

Protein Name

 Inward rectifier potassium channel 2 

Protein Synonyms/Alias

 Inward rectifier K(+) channel Kir2.1; IRK-1; Potassium channel, inwardly rectifying subfamily J member 2 

Gene Name

 Kcnj2 

Gene Synonyms/Alias

 Irk1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
338	FEEKHYYKVDYSRFH	ubiquitination	[1]
346	VDYSRFHKTYEVPNT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. 

Sequence Annotation

 MOTIF 142 147 Selectivity filter (By similarity).
 MOTIF 426 428 PDZ-binding (Potential).  

Keyword

 3D-structure; Complete proteome; Ion channel; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 428 AA 

Protein Sequence

Gene Ontology

 GO:0030425; C:dendrite; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031224; C:intrinsic to membrane; ISS:UniProtKB.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005242; F:inward rectifier potassium channel activity; ISS:UniProtKB.
 GO:0015693; P:magnesium ion transport; IDA:MGI.
 GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
 GO:0086001; P:regulation of cardiac muscle cell action potential; IMP:MGI. 

Interpro

 IPR014756; Ig_E-set.
 IPR016449; K_chnl_inward-rec_Kir.
 IPR003271; K_chnl_inward-rec_Kir2.1.
 IPR013518; K_chnl_inward-rec_Kir_cyto.
 IPR013673; K_chnl_inward-rec_Kir_N. 

Pfam

 PF01007; IRK
 PF08466; IRK_N 

SMART

  

PROSITE

  

PRINTS

 PR01324; KIR21CHANNEL.
 PR01320; KIRCHANNEL.