UniProt Accession

 CD11B_HUMAN; P21127; O95265; Q12817; Q12818; Q12819; Q12820; Q12822; Q8N530; Q9NZS5; Q9UBJ0; Q9UBQ1; Q9UBR0; Q9UNY2; Q9UP57; Q9UP58; Q9UP59 

Genbank Protein ID

 M37712; M88563; M88553; M88554; M88555; M88558; M88559; M88560; M88561; M88562; U04815; U04816; U04817; U04818; U04824; AF067512; AF067513; AF067514; AF067515; AF067516; AF067517; AF080683; AF080685; AF080686; AF080687; AF080688; AF092429; AF092430; AF080678; AF080679; AF080680; AF080681; AF080682; AF080683; AF080685; AF080686; AF080687; AF080688; AF092429; AF092430; AF080678; AF080679; AF080680; AF080681; AF080682; AF080683; AF080685; AF080686; AF080687; AF080688; AF092429; AF092430; AF080678; AF080679; AF080680; AF080681; AF080682; AF080683; AF080685; AF080686; AF080687; AF080688; AF092429; AF092430; AF080678; AF080679; AF080680; AF080681; AF080682; AF080683; AF092430; AF080678; AF080679; AF080680; AF080681; AF080682; AF174497 

Genbank Nucleotide ID

 AAA36406.1; AAB59449.1; AAB59449.1; AAB59449.1; AAB59449.1; AAB59449.1; AAB59449.1; AAB59449.1; AAB59449.1; AAB59449.1; AAA19581.1; AAA19582.1; AAA19583.1; AAA19584.1; AAA19586.1; AAC72077.1; AAC72078.1; AAC72079.1; AAC72080.1; AAC72081.1; AAC72082.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83662.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83663.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83664.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83665.1; AAC83666.1; AAC83666.1; AAC83666.1; AAC83666.1; AAC83666.1; AAC83666.1; AAC83666.1; AAF36538.1 

Protein Name

 Cyclin-dependent kinase 11B 

Protein Synonyms/Alias

 Cell division cycle 2-like protein kinase 1; CLK-1; Cell division protein kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1; p58 CLK-1 

Gene Name

 CDK11B 

Gene Synonyms/Alias

 CDC2L1; CDK11; PITSLREA; PK58 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
294	NYVEHDLKSLMETMK	ubiquitination	[1]
301	KSLMETMKQPFLPGE	ubiquitination	[1]
430	DLGTPSEKIWPGYSE	ubiquitination	[1]
442	YSELPAVKKMTFSEH	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. 

Sequence Annotation

 DOMAIN 438 723 Protein kinase.
 NP_BIND 444 452 ATP (By similarity).
 ACT_SITE 562 562 Proton acceptor (By similarity).
 BINDING 467 467 ATP (By similarity).
 MOD_RES 47 47 Phosphoserine (By similarity).
 MOD_RES 115 115 Phosphoserine.
 MOD_RES 277 277 Phosphoserine (By similarity).
 MOD_RES 283 283 Phosphoserine (By similarity).
 MOD_RES 482 482 Phosphoserine; by CDK7.
 MOD_RES 488 488 Phosphothreonine; by CDK7.
 MOD_RES 589 589 Phosphoserine.
 MOD_RES 594 594 Phosphotyrosine.
 MOD_RES 595 595 Phosphothreonine.
 MOD_RES 751 751 Phosphothreonine (By similarity).
 MOD_RES 752 752 Phosphoserine (By similarity).  

Keyword

 Alternative initiation; Alternative splicing; Apoptosis; ATP-binding; Cell cycle; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 795 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; NAS:UniProtKB.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007067; P:mitosis; NAS:UniProtKB.
 GO:0001558; P:regulation of cell growth; IEP:UniProtKB.
 GO:0050684; P:regulation of mRNA processing; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS